Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder

REYNOLDS, Lindsay M. and REYNOLDS, Gavin (2011). Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder. Journal of Psychiatric Research, 45 (1), 54-59.

Full text not available from this repository.
Link to published version:: https://doi.org/10.1016/j.jpsychires.2010.05.001
Related URLs:

    Abstract

    There is substantial evidence for the involvement of the hippocampus and subcortical regions in the neuropathology of schizophrenia. Deficits of N-acetylaspartate (NAA) have been found in schizophrenia and bipolar disorder which may reflect neuronal loss and/or dysfunction. N-acetylaspartylglutamate (NAAG) is the most abundant peptide transmitter in the mammalian nervous system. It is an agonist at presynaptic metabotropic glutamate receptors mGluR3, inhibiting glutamate release. NAA and NAAG and were measured in hippocampal, striatal, amygdala and cingulate gyrus regions of human postmortem tissue from controls and subjects with schizophrenia, bipolar disorder and major depressive disorder. There are significant deficits in hippocampal NAA concentrations in all patient groups. In the amygdala there are significant NAA deficits in schizophrenia and depression and significant deficits of NAAG in the amygdala in the depression group. The deficits in NAA reported in this study confirm the importance of hippocampal and other subcortical structures in the neuropathology of the major psychiatric disorders.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1016/j.jpsychires.2010.05.001
    Page Range: 54-59
    Depositing User: Users 3084 not found.
    Date Deposited: 14 Sep 2012 13:00
    Last Modified: 09 Oct 2018 12:47
    URI: http://shura.shu.ac.uk/id/eprint/5860

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics