Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging.

DJIDJA, Marie-Claude, FRANCESE, Simona, CLAUDE, Emmanuelle, LOADMAN, Paul, SUTTON, Chris, SHYNDER, Steve, COOPER, Patricia, PATTERSON, Laurence H, CAROLAN, Vikki and CLENCH, Malcolm (2013). Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging. Current Analytical Chemistry, 9 (2), 212-225.

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Link to published version:: https://doi.org/10.2174/157341113805218884
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    Abstract

    In situ investigation and characterisation of hypoxia-related protein markers in AQ4N treated tumour xenografts. MALDI-IMS-MSI enabled the visualisation of the distribution of AQ4N and AQ4 within the tissue sections, hence the selective localisation hypoxic tissue regions. Protein distribution and identification were obtained directly from AQ4N treated and non treated tumour tissue sections after in situ digestion.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.2174/157341113805218884
    Page Range: 212-225
    Depositing User: Rebecca Jones
    Date Deposited: 23 Jul 2012 15:19
    Last Modified: 18 Mar 2021 05:11
    URI: http://shura.shu.ac.uk/id/eprint/5550

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