Nutrimetabolomics: development of a bio-identification toolbox to determine the bioactive compounds in grape juice.

SAVAGE, Angela K, TUCKER, Gregory, VAN DUYNHOVEN, John PM, WULFERT, Florian and DAYKIN, Clare A (2009). Nutrimetabolomics: development of a bio-identification toolbox to determine the bioactive compounds in grape juice. Bioanalysis, 1 (9), 1537-1549.

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Link to published version:: https://doi.org/10.4155/BIO.09.147
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    Abstract

    Background: Grape juice and related products have previously been associated with many health benefits, such as protection against cardiovascular disease. Current consensus is that the polyphenols are the likely bioactive species in these products. Results: Extracts of commercially available grape juices exhibited biological antioxidant activities ranging from 19.30 to 3099.51 µM trolox equivalents, as determined by cell-based assay in which J774 macrophages were stimulated with lipopolysaccaride at a concentration of 100 µg/ml for 1 h. Partial least-squares regression was then used to determine covariance between the antioxidant activity and 400 MHz 1H NMR spectral profiles using models with R2X and R2Y values of 0.64 and 0.95, respectively, using three latent variables: the Q2(cum) was 0.63. Hydroxycinnamic acids and their derivatives were identified as being the most positively correlated with the antioxidant activity. Conclusion: The work presented here describes a strategy for the bioinformatic linkage of plant metabolomic data with in vitro biological activity as an initial step towards determining structure–activity relationships.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.4155/BIO.09.147
    Page Range: 1537-1549
    Depositing User: Rebecca Jones
    Date Deposited: 21 Feb 2012 15:33
    Last Modified: 11 Oct 2018 08:39
    URI: http://shura.shu.ac.uk/id/eprint/4691

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