ABDEL-RAHMAN, MA, ABDEL-NABI, IM, EL-NAGGAR, MS, ABBAS, OA and STRONG, Peter (2011). Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum. Comparative Biochemistry and Physiology Toxicology Pharmacology, 154 (4), 318-325.Full text not available from this repository.
A combination of proteomic and biochemical assays was used to examine variations in the venom of Conus vexillum taken from two locations (Hurgada and Sharm El-Shaikh) in the Red Sea, Egypt. Using MALDI/TOF-MS, a remarkable degree of intra-species variation between venom samples from both locations was identified. To evaluate variability in the cytotoxic effects of Conus venom, mice were injected with the same dose from each location. The oxidative stress biomarkers malondialdehyde (MDA), protein carbonyl content (PCC), antioxidants glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC) and nitric oxide (NO), were measured 3, 6, 9 and 12h post venom injection. The venoms induced a significant increase in the levels of PCC, MDA, NO, GSH and CAT. The venoms significantly inhibited the activity of SOD and reduced the TAC. Toxicological data showed that the venom obtained from Hurgada was more potent than that obtained from Sharm El-Shaikh. It can be concluded that: (1) the venom of the same Conus species from different regions is highly diversified (2) the venoms from different locations reflect clear differences in venom potency and (3) the cytotoxic effects of C. vexillum venom can be attributed to its ability to induce oxidative stress.
|Research Institute, Centre or Group:||Biomedical Research Centre|
|Depositing User:||Rebecca Jones|
|Date Deposited:||09 Feb 2012 11:18|
|Last Modified:||09 Feb 2012 11:18|
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