Contrasting effects of physical wear on elution of two antibiotics from orthopaedic cement

DODDS, Stephen, SMITH, Thomas Smith, AKID, Robert, STEPHENSON, J, NICHOL, Tim, BANERJEE, RD, STOCKLEY, I and TOWNSEND, R (2011). Contrasting effects of physical wear on elution of two antibiotics from orthopaedic cement. Antimicrobial Agents and Chemotherapy, 56 (3), 1471-1475.

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Link to published version:: https://doi.org/10.1128/AAC.01588-10
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    Abstract

    The use of antibiotics as a supplement to bone cement for the purposes of providing a local release of antibiotics is common practice in arthroplasty surgery and the kinetics of elution of the antibiotics in such systems have been investigated previously. However, in these previous studies no account has been taken of the potential effects that wear may have on the elution kinetics of the antibiotic. Here we have modified an existing wear testing rig to allow the simultaneous study of the elution kinetics of bone cement samples containing antibiotics being subjected to immersion only and immersion and conjoint wear. The results show contrasting effects with two commonly used antibiotics. Bone cement containing daptomycin showed no substantial change in antibiotic elution due to wear, whilst cement containing gentamicin (the most commonly used antibiotic in this application) in contrast demonstrated a substantial reduction in the rate of antibiotic elution when wear was applied. Scanning electron microscopy revealed a possible explanation for these diverse results, due to wear-induced ‘sealing’ of the surface in conjunction with the crystal morphology of the antibiotic.

    Item Type: Article
    Additional Information: Published ahead of print December 2011
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1128/AAC.01588-10
    Page Range: 1471-1475
    Depositing User: Rebecca Jones
    Date Deposited: 08 Feb 2012 17:11
    Last Modified: 18 Mar 2021 10:15
    URI: http://shura.shu.ac.uk/id/eprint/4507

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