DODDS, Stephen, SMITH, Thomas Smith, AKID, Robert, STEPHENSON, J, NICHOL, Tim, BANERJEE, RD, STOCKLEY, I and TOWNSEND, R (2011). Contrasting effects of physical wear on elution of two antibiotics from orthopaedic cement. Antimicrobial Agents and Chemotherapy, 56 (3), 1471-1475.Full text not available from this repository.
The use of antibiotics as a supplement to bone cement for the purposes of providing a local release of antibiotics is common practice in arthroplasty surgery and the kinetics of elution of the antibiotics in such systems have been investigated previously. However, in these previous studies no account has been taken of the potential effects that wear may have on the elution kinetics of the antibiotic. Here we have modified an existing wear testing rig to allow the simultaneous study of the elution kinetics of bone cement samples containing antibiotics being subjected to immersion only and immersion and conjoint wear. The results show contrasting effects with two commonly used antibiotics. Bone cement containing daptomycin showed no substantial change in antibiotic elution due to wear, whilst cement containing gentamicin (the most commonly used antibiotic in this application) in contrast demonstrated a substantial reduction in the rate of antibiotic elution when wear was applied. Scanning electron microscopy revealed a possible explanation for these diverse results, due to wear-induced ‘sealing’ of the surface in conjunction with the crystal morphology of the antibiotic.
|Additional Information:||Published ahead of print December 2011|
|Research Institute, Centre or Group:||Biomedical Research Centre|
|Depositing User:||Rebecca Jones|
|Date Deposited:||08 Feb 2012 17:11|
|Last Modified:||21 Sep 2012 12:28|
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