Anti-angiogenic properties of ADAMTS-4 in vitro.

HSU, Y P, STATON, C A, CROSS, Neil and BUTTLE, D J (2012). Anti-angiogenic properties of ADAMTS-4 in vitro. International Journal Of Experimental Pathology, 93 (1), 70-77.

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Link to published version:: 10.1111/j.1365-2613.2011.00802.x

Abstract

Angiogenesis is an indispensable mechanism in development and in many pathologies, including cancer, synovitis and aberrant wound healing. Many angiogenic stimulators and inhibitors have been investigated, and some have progressed to the clinic. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a group of multifunctional proteinases. ADAMTS-1 and ADAMTS-8 have been reported to be anti-angiogenic. Here, we provide evidence that ADAMTS-4, like ADAMTS-1, is expressed by endothelial cells and binds to vascular endothelial groth factor (VEGF). Moreover, ADAMTS-4 inhibited human dermal microvascular endothelial cells (HuDMEC) VEGF-stimulated VEGF receptor (R) R2 phosphorylation, differentiation and migration, suggesting that ADAMTS-4 may be a novel anti-angiogenic molecule.

Item Type: Article
Research Institute, Centre or Group: Biomedical Research Centre
Identification Number: 10.1111/j.1365-2613.2011.00802.x
Depositing User: Rebecca Jones
Date Deposited: 08 Mar 2012 08:53
Last Modified: 08 Mar 2012 08:53
URI: http://shura.shu.ac.uk/id/eprint/4493

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