Cholinergic modulation of spontaneous activity in bladder strips from the diabetic rat : effect of the mucosa.

VAHABI, B, LAWSON, Kim, MCKAY, Neil and SELLERS, Donna (2009). Cholinergic modulation of spontaneous activity in bladder strips from the diabetic rat : effect of the mucosa. European Eurology Supplements, 8 (4), p. 177.

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Link to published version:: 10.1016/S1569-9056(09)60232-3

Abstract

Spontaneous contractions (SCs) have been shown to be increased in the overactive bladder and animal models of detrusor overactivity and may underlie the abnormal increases in intravesical pressure which lead to urgency, frequency and urge incontinence. We have previously shown increased SCs in bladder strips from a diabetic rat model. It has been suggested that SCs may be enhanced by leakage of small amounts of acetylcholine from intramural nerves (1). The aim was to study cholinergic modulation of SCs in bladder strips from streptozotocin-induced diabetic rats and the role of the mucosa.

Item Type: Article
Research Institute, Centre or Group: Biomedical Research Centre
Identification Number: 10.1016/S1569-9056(09)60232-3
Depositing User: Rebecca Jones
Date Deposited: 25 Jan 2012 10:27
Last Modified: 25 Jan 2012 10:27
URI: http://shura.shu.ac.uk/id/eprint/4372

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