Expression of chemokines in cerebrospinal fluid and serum of patients with chronic inflammatory demyelinating polyneuropathy

MAHAD, D. J., HOWELL, S. J. L. and WOODROOFE, N. (2002). Expression of chemokines in cerebrospinal fluid and serum of patients with chronic inflammatory demyelinating polyneuropathy. Journal of neurology neurosurgery and psychiatry, 73 (3), 320-323.

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Link to published version:: 10.1136/jnnp.73.3.320

Abstract

Chemokines are likely to contribute to the pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP), as evidenced by data from experimental autoimmune neuritis. The and ß chemokines in the cerebrospinal fluid (CSF) and serum from patients with CIDP were analysed using an enzyme linked immunosorbent assay. CXCL9, CXCL10, and CCL3 were raised in the CSF in CIDP compared with controls and non-demyelinating neuropathies (p < 0.001). Although the CSF levels of CCL2 were significantly higher than the serum levels for all groups, the difference between groups was not significant. CXCL9, CXCL10, and CCL3 may contribute to the pathogenesis of CIDP by recruiting inflammatory T cells and monocytes to spinal nerve roots, while CCL2 is likely to play a physiological role.

Item Type: Article
Uncontrolled Keywords: chemokines, chronic inflammatory demyelinating polyneuropathy
Research Institute, Centre or Group: Biomedical Research Centre
Identification Number: 10.1136/jnnp.73.3.320
Depositing User: Ann Betterton
Date Deposited: 13 Feb 2008
Last Modified: 09 Dec 2009 18:23
URI: http://shura.shu.ac.uk/id/eprint/429

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