Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion mesobuthus tamulus

STRONG, P. N., CLARK, G. S., ARMUGAM, A., DE-ALLIE, F. A., JOSEPH, J. S., YEMUL, V., DESHPANDE, J. M., KAMAT, R., GADRE, S. V., GOPALAKRISHNAKONE, P., KINI, R. M., OWEN, D. G. and JEYASEELAN, K. (2000). Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion mesobuthus tamulus. Archives of biochemistry and biophysics, 385 (1), 138-144.

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Link to published version:: https://doi.org/10.1006/abbi.2000.2135
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    Abstract

    We have characterized tamulustoxin, a novel 35-amino-acid peptide found in the venom of the Indian red scorpion (Mesobuthus tamulus). Tamulustoxin was identified through a [125I]toxin I screen, designed to identify toxins that block voltage-activated potassium channels. Tamulustoxin has also been cloned by RT-PCR, using RNA extracted from scorpion venom glands. Tamulustoxin shares no homology with other scorpion venom toxins, although the positions of its six cysteine residues would suggest that it shares the same structural scaffold. Tamulustoxin rapidly inhibited both peak and steady-state currents (18.9 +/- 1.0 and 37 +/- 1.1%, respectively) produced by injecting CHO cells with mRNA encoding the hKv1.6 channel.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1006/abbi.2000.2135
    Page Range: 138-144
    Depositing User: Ann Betterton
    Date Deposited: 11 Mar 2008
    Last Modified: 19 Mar 2021 01:15
    URI: http://shura.shu.ac.uk/id/eprint/415

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