Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion mesobuthus tamulus

STRONG, P. N., CLARK, G. S., ARMUGAM, A., DE-ALLIE, F. A., JOSEPH, J. S., YEMUL, V., DESHPANDE, J. M., KAMAT, R., GADRE, S. V., GOPALAKRISHNAKONE, P., KINI, R. M., OWEN, D. G. and JEYASEELAN, K. (2000). Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion mesobuthus tamulus. Archives of biochemistry and biophysics, 385 (1), 138-144.

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Abstract

We have characterized tamulustoxin, a novel 35-amino-acid peptide found in the venom of the Indian red scorpion (Mesobuthus tamulus). Tamulustoxin was identified through a [125I]toxin I screen, designed to identify toxins that block voltage-activated potassium channels. Tamulustoxin has also been cloned by RT-PCR, using RNA extracted from scorpion venom glands. Tamulustoxin shares no homology with other scorpion venom toxins, although the positions of its six cysteine residues would suggest that it shares the same structural scaffold. Tamulustoxin rapidly inhibited both peak and steady-state currents (18.9 +/- 1.0 and 37 +/- 1.1%, respectively) produced by injecting CHO cells with mRNA encoding the hKv1.6 channel.

Item Type:	Article
Research Institute, Centre or Group:	Biomedical Research Centre
Identification Number:	10.1006/abbi.2000.2135
Depositing User:	Ann Betterton
Date Deposited:	11 Mar 2008
Last Modified:	09 Dec 2009 18:23
URI:	http://shura.shu.ac.uk/id/eprint/415

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