Use of magnetic resonance angiography to select candidates with recently symptomatic carotid stenosis for surgery: systematic review

WESTWOOD, Marie E., KELLY, Steven, BERRY, Elizabeth, BAMFORD, John M., GOUGH, Michael J., AIREY, C. Mark, DAVIES, Linda M., MEANEY, James F., CULLINGWORTH, Jane and SMITH, Michael A, (2002). Use of magnetic resonance angiography to select candidates with recently symptomatic carotid stenosis for surgery: systematic review. British Medical Journal (BMJ), 324 (7331), 198-201.

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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC64789/

Abstract

Objective. To determine if sufficient evidence exists to support the use of magnetic resonance angiography as a means of selecting patients with recently symptomatic high grade carotid stenosis for surgery.

Design. Systematic review of published research on the diagnostic performance of magnetic resonance angiography, 1990-9.

Main outcome measures. Performance characteristics of diagnostic test.

Results. 126 potentially relevant articles were identified, but many articles failed to examine the performance of magnetic resonance angiography as a diagnostic test at the surgical decision thresholds used in major clinical trials on endarterectomy. 26 articles were included in a meta-analysis that showed a maximal joint sensitivity and specificity of 99% (95% confidence interval 98% to 100%) for identifying 70-99% stenosis and 90% (81% to 99%) for identifying 50-99% stenosis. Only four articles evaluated contrast enhanced magnetic resonance angiography.

Conclusions. Magnetic resonance angiography is accurate for selecting patients for carotid endarterectomy at the surgical decision thresholds established in the major endarterectomy trials, but the evidence is not very robust because of the heterogeneity of the studies included. Research is needed to determine the diagnostic performance of the most recent developments in magnetic resonance angiography, including contrast enhanced techniques, as well as to assess the impact of magnetic resonance angiography on surgical decision making and outcomes.

Item Type: Article
Research Institute, Centre or Group: Centre for Health and Social Care Research
Depositing User: Ann Betterton
Date Deposited: 16 Mar 2011 12:29
Last Modified: 16 Mar 2011 12:29
URI: http://shura.shu.ac.uk/id/eprint/3394

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