ALBARBAR, Balid, DUNNILL, Christopher and GEORGOPOULOS, Nik (2015). Regulation of cell fate by lymphotoxin (LT) receptor signalling: Functional differences and similarities of the LT system to other TNF superfamily (TNFSF) members. Cytokine & growth factor reviews, 26 (6), 659-671.
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Abstract
The role of TNFR family members in regulating cell fate both in the immune system and in non-lymphoid tissues has been under extensive research for decades. Moreover, the ability of several family members (death receptors) to induce death (mainly via apoptosis) represents a promising target for cancer therapy. Many studies have focused mostly on death receptors such as TNFRI, Fas and TRAIL-R due to their strong pro-apoptotic potential. Yet, cell death can be triggered via non-classical death receptors, and the lymphotoxin (LT) system represents a very good example of such a TNFR subfamily. Here we provide a comprehensive review of intracellular signalling pathways and cellular responses to LT-specific signalling, and compare for the first time the LT system to other TNFRs, such as CD40. Our aim is to highlight that non-classical TNFR-TNFL dyads such as the LT system demonstrate more complex, cell-type and context-specific capabilities. Understanding these complexities will permit a better understanding of the biological mechanisms via which non-death domain-containing TNFRs induce cell death, but may also allow the design of better therapeutic strategies.
Item Type: | Article |
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Uncontrolled Keywords: | Animals; Humans; Tumor Necrosis Factors; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Cell Death; Apoptosis; Cell Differentiation; Lymphotoxin-alpha; CD40 Antigens; Apoptosis; CD40; Cell signalling; Lymphotoxin; Receptor cross-linking; Animals; Apoptosis; CD40 Antigens; Cell Death; Cell Differentiation; Humans; Lymphotoxin-alpha; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Tumor Necrosis Factors; 0601 Biochemistry and Cell Biology; 1103 Clinical Sciences; Immunology; 3101 Biochemistry and cell biology |
Identification Number: | https://doi.org/10.1016/j.cytogfr.2015.05.001 |
Page Range: | 659-671 |
SWORD Depositor: | Symplectic Elements |
Depositing User: | Symplectic Elements |
Date Deposited: | 08 Apr 2024 13:46 |
Last Modified: | 08 Apr 2024 13:46 |
URI: | https://shura.shu.ac.uk/id/eprint/33186 |
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