The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

SIDELI, Lucia, AAS, Monica, QUATTRONE, Diego, LA BARBERA, Daniele, LA CASCIA, Caterina, FERRARO, Laura, ALAMEDA, Luis, VELTHORST, Eva, TROTTA, Giulia, TRIPOLI, Giada, SCHIMMENTI, Adriano, FONTANA, Andrea, GAYER-ANDERSON, Charlotte, STILO, Simona, SEMINERIO, Fabio, SARTORIO, Crocettarachele, MARRAZZO, Giovanna, LASALVIA, Antonio, TOSATO, Sarah, TARRICONE, Ilaria, BERARDI, Domenico, D'ANDREA, Giuseppe, EU-GEI WP2 GROUP, , ARANGO, Celso, ARROJO, Manuel, BERNARDO, Miguel, BOBES, Julio, SANJUÁN, Julio, SANTOS, Jose Luis, MENEZES, Paulo Rossi, DEL-BEN, Cristina Marta, JONGSMA, Hannah E., JONES, Peter B., KIRKBRIDE, James B., LLORCA, Pierre-Michel, TORTELLI, Andrea, PIGNON, Baptiste, DE HAAN, Lieuwe, SELTEN, Jean-Paul, VAN OS, Jim, RUTTEN, Bart P., BENTALL, Richard, DI FORTI, Marta, MURRAY, Robin M., MORGAN, Craig and FISHER, Helen L. (2023). The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study. Social psychiatry and psychiatric epidemiology, 58 (10), 1573-1580.

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Abstract

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Item Type:	Article
Contributors:	Loureiro, Camila [0000-0002-0239-5064]
Uncontrolled Keywords:	EU-GEI WP2 Group; Humans; Case-Control Studies; Cognition; Psychotic Disorders; Schizophrenia; Child Abuse; Adult; Child; Childhood adversity; Cognition; Family history of psychosis; First episode; Polygenic risk score; Psychosis; Adult; Humans; Child; Case-Control Studies; Psychotic Disorders; Schizophrenia; Cognition; Child Abuse; 1103 Clinical Sciences; 1701 Psychology; 1702 Cognitive Sciences; Psychiatry; 4202 Epidemiology; 4206 Public health; 5203 Clinical and health psychology
Identification Number:	https://doi.org/10.1007/s00127-023-02513-0
Page Range:	1573-1580
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	13 Feb 2024 12:11
Last Modified:	14 Feb 2024 02:02
URI:	https://shura.shu.ac.uk/id/eprint/33176

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