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LOUREIRO, Camila, CORSI-ZUELLI, Fabiana, FACHIM, Helene Aparecida, SHUHAMA, Rosana, CHAGAS, Natália Mota de Souza, MENEZES, Paulo Rossi, DEL-BEN, Cristina Marta and LOUZADA-JUNIOR, Paulo (2021). Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis. Ciencia & saude coletiva, 26 (3), 1085-1094.
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Abstract
We investigated the feasibility of including plasma anti-NMDAR antibody screening in the assessment of first-episode psychosis patients in an early intervention programme in the Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA in 166 patients (64.0% men), 166 matched population-based controls and 76 patients' siblings (30.3% men). Fisher's exact test and ANOVA were performed. Positive anti-NMDAR antibody patients were more often observed in bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences were observed. Our results are not conclusive regarding the inclusion of plasma anti-NMDAR IgG antibodies in differential diagnostic protocols for psychosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans; Receptors, N-Methyl-D-Aspartate; Prevalence; Bipolar Disorder; Psychotic Disorders; Schizophrenia; Female; Male; Bipolar Disorder; Female; Humans; Male; Prevalence; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Schizophrenia; 1117 Public Health and Health Services; Public Health; 4206 Public health |
| Identification Number: | https://doi.org/10.1590/1413-81232021263.07552019 |
| Page Range: | 1085-1094 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 12 Mar 2024 13:24 |
| Last Modified: | 12 Mar 2024 13:30 |
| URI: | https://shura.shu.ac.uk/id/eprint/33173 |
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