DUNSMORE, C. J., MILLER, K., BLAKE, K. L., PATCHING, S. G., HENDERSON, P. J. F., GARNETT, J. A., STUBBINGS, W. J., PHILLIPS, S. E. V., PALESTRANT, D. J. and ANGELES, J. de L. (2008). 2-Aminotetralones: Novel inhibitors of MurA and MurZ. Bioorganic & Medicinal Chemistry Letters, 18 (5), 1730-1734.
Full text not available from this repository.Abstract
Several 2-aminotetralones were identified as novel inhibitors of the bacterial enzymes MurA and MurZ. A number of these inhibitors demonstrated antibacterial activity against Staphylococcus aureus and Escherichia coli with MICs in the range 8-128 microg/ml. Based on structure-activity relationships we propose that the alpha-aminoketone functionality is responsible for the inhibitory activity and evidence is provided to support a covalent mode of action involving the C115 thiol group of MurA/MurZ.
Item Type: | Article |
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Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.1016/j.bmcl.2008.01.089 |
Page Range: | 1730-1734 |
Depositing User: | Users 4 not found. |
Date Deposited: | 28 Feb 2011 14:47 |
Last Modified: | 18 Mar 2021 21:00 |
URI: | https://shura.shu.ac.uk/id/eprint/3233 |
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