Tail-anchored membrane proteins: exploring the complex diversity of tail-anchored-protein targeting in plant cells

ABELL, Benjamin and MULLEN, Robert T. (2011). Tail-anchored membrane proteins: exploring the complex diversity of tail-anchored-protein targeting in plant cells. Plant Cell Reports, 30 (2), 137-151.

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Abstract

Tail-anchored (TA) proteins are special class of integral membrane proteins that in recent years have received a considerable amount of attention due to their diverse cellular functions and unique targeting and insertion mechanisms. Defined by the presence of a single, hydrophobic membrane-spanning domain at or near their C terminus, TA proteins must be inserted into membranes post-translationally and are orientated such that their larger N-terminal domain (most often the functional domain) faces the cytosol, while their shorter C-terminal domain faces the interior of the organelle. The C-terminal domain of TA proteins also usually contains the information responsible for their selective targeting to the proper subcellular membrane, a process that, based primarily on studies with yeasts and mammals, appears to be highly complex due to the presence of multiple pathways. Within this context, we discuss here the biogenesis of plant TA proteins and the potential for hundreds of new TA proteins identified via bioinformatics screens to contribute to the already remarkable number of roles that this class of membrane proteins participates in throughout plant growth and development.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Biomedical Research Centre
Identification Number:	https://doi.org/10.1007/s00299-010-0925-6
Page Range:	137-151
Depositing User:	Users 4 not found.
Date Deposited:	22 Feb 2011 17:04
Last Modified:	18 Mar 2021 21:00
URI:	https://shura.shu.ac.uk/id/eprint/3220

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