Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study

YASSIN, Aksam, KELLY, Daniel, NETTLESHIP, Joanne, TALIB, Raidh, AL-ZOUBI, Raed M, ABOUMARZOUK, Omar M and ALBABA, Bassam (2023). Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study. The Aging Male, 26 (1): 2220567.

Preview

PDF Kelly-TestosteroneTreatmentChange(VoR).pdf - Published Version Creative Commons Attribution. Download (1MB) | Preview

Abstract

Functional hypogonadism is a condition characterized by low testosterone concentrations, occurring more commonly in men as they age. The International Prostate Symptom Score (IPSS) is used to categorize the severity of lower urinary tract symptoms (LUTS) and related symptoms in hypogonadal men. Testosterone therapy (TTh) has previously shown potential in improving total IPSS in men with hypogonadism. However, concerns regarding the effects of urinary function following TTh often prevent treatment in hypogonadal men. To explore this further, two population-based single-center, prospective, cumulative registry studies were combined to contribute to a total population of 1176 men with symptoms of hypogonadism. The total population was separated into a TTh group receiving testosterone undecanoate (TU) for up to 12 years and a control group that did not receive treatment. IPSS was recorded at both baseline and at final recorded visit for each patient. Long-term TTh with TU in hypogonadal men resulted in significant improvements in IPSS categories, even in patients with severe symptoms at baseline. In the control group, untreated hypogonadal men experienced a worsening of IPSS categories. These data indicate that TTh improves LUTS in men with hypogonadism and suggest that previous concerns regarding urinary function may have been overstated.

Item Type:	Article
Uncontrolled Keywords:	Hypogonadism; LUTS; IPSS; testosterone treatment; prostate cancer; Hypogonadism; IPSS; LUTS; prostate cancer; testosterone treatment; Male; Humans; Prostate; Prospective Studies; Testosterone; Hypogonadism; Registries; 1701 Psychology; Endocrinology & Metabolism; 5201 Applied and developmental psychology; 5203 Clinical and health psychology
Identification Number:	https://doi.org/10.1080/13685538.2023.2220567
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	23 Jun 2023 15:37
Last Modified:	11 Oct 2023 13:48
URI:	https://shura.shu.ac.uk/id/eprint/32051

Actions (login required)

View Item

Downloads

Publication Metrics