High-intensity exercise prescription guided by heart rate variability in breast cancer patients: a study protocol for a randomized controlled trial

LAVÍN-PÉREZ, Ana Myriam, COLLADO-MATEO, Daniel, HINOJO GONZÁLEZ, Carmen, DE JUAN FERRÉ, Ana, RUISÁNCHEZ VILLAR, Cristina, MAYO, Xián and JIMENEZ GUTIERREZ, Alfonso (2023). High-intensity exercise prescription guided by heart rate variability in breast cancer patients: a study protocol for a randomized controlled trial. BMC Sports Science, Medicine and Rehabilitation, 15 (1): 28.

13102_2023_Article_634.pdf - Published Version
Creative Commons Attribution.

Download (1MB) | Preview
Official URL: https://bmcsportsscimedrehabil.biomedcentral.com/a...
Open Access URL: https://bmcsportsscimedrehabil.biomedcentral.com/c... (Published version)
Link to published version:: https://doi.org/10.1186/s13102-023-00634-2


Background: Breast cancer is a chronic disease with a large growth in its treatments, prognosis, improvements, side effects and rehabilitation therapies research. These advances have also highlighted the need to use physical exercise as a countermeasure to reduce the cardiotoxicity of pharmacological treatments, increase patients' strength and quality of life and improve body composition, physical condition and mental health. However, new investigations show the need for a closed exercise individualisation to produce higher physiological, physical and psychological benefits in remote exercise programs. To this end, the present study will use, in a novel way in this population, heart rate variability (HRV) as a measure for prescribing high-intensity training. Thus, the primary objective of this randomised clinical trial is to analyse the effects of a high-intensity exercise program daily guided by HRV, a preplanned moderate to high-intensity exercise intervention and a usual care group, in breast cancer patients after chemotherapy and radiotherapy treatments. Methods: For this purpose, a 16-week intervention will be carried out with 90 breast cancer patients distributed in 3 groups (a control group, a moderate to high-intensity preplanned exercise group and a high-intensity exercise group guided by HRV). Both physical exercise interventions will be developed remotely and supervised including strength and cardiovascular exercises. Physiological variables, such as cardiotoxicity, biomarkers, lipid profile, glucose, heart rate and blood pressure; physical measures like cardiorespiratory capacity, strength, flexibility, agility, balance and body composition; and psychosocial variables, as health-related quality of life, fatigue, functionality, self-esteem, movement fear, physical exercise level, anxiety and depression will be measure before, after the intervention and 3 and 6 months follow up. Discussion: Personalized high-intensity exercise could be a promising exercise intervention in contrast to moderate-intensity or usual care in breast cancer patients to reach higher clinical, physical and mental effects. In addition, the novelty of controlling HRV measures daily may reflect exercise effects and patients' adaptation in the preplanned exercise group and a new opportunity to adjust intensity. Moreover, findings may support the effectiveness and security of physical exercise remotely supervised, although with high-intensity exercise, to reach cardiotoxicity improvements and increase physical and psychosocial variables after breast cancer treatments. Trial registration ClinicalTrials.gov nº NCT05040867 (https://clinicaltrials.gov/ct2/show/record/NCT05040867).

Item Type: Article
Additional Information: ** From Springer Nature via Jisc Publications Router ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ ** Acknowledgements: Not applied. Trial status: Recruiting participants for the research. **Journal IDs: eissn 2052-1847 **Article IDs: publisher-id: s13102-023-00634-2; manuscript: 634 **History: collection 12-2023; online 08-03-2023; published_online 08-03-2023; registration 17-02-2023; accepted 16-02-2023; submitted 28-08-2022
Uncontrolled Keywords: Study Protocol, NCT05040867, NCT, Breast cancer survivors, HIT, Strength training, Remote and supervised exercise, Cardiotoxicity, Physical effects, Psychosocial effects
Identification Number: https://doi.org/10.1186/s13102-023-00634-2
SWORD Depositor: Colin Knott
Depositing User: Colin Knott
Date Deposited: 10 Mar 2023 12:30
Last Modified: 11 Oct 2023 16:45
URI: https://shura.shu.ac.uk/id/eprint/31638

Actions (login required)

View Item View Item


Downloads per month over past year

View more statistics