Biochemistry and Molecular Biology of Methane Monooxygenase

MURRELL, J. C. and SMITH, T. J. (2010). Biochemistry and Molecular Biology of Methane Monooxygenase. In: TIMMIS, K. N., (ed.) Handbook of Hydrocarbon and Lipid Microbiology. Springer, 1045-1055.

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Link to published version:: https://doi.org/10.1007/978-3-540-77587-4_73
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    Abstract

    Methane oxidizing bacteria (methanotrophs) are a unique group of aerobic bacteria that can gain all of their carbon and energy requirements from methane. The enzymes that catalyze the first step in the bacterial methane oxidation pathway, the oxidation of methane to methanol, are called methane monooxygenases. These are remarkable enzymes because methane is chemically very stable and to convert methane to methanol chemically requires expensive catalysts, high temperatures and pressures. There are two types of methane monooxygenase that occur in methanotrophs, a membrane-bound, particulate methane monooxygenase and a cytoplasmic, soluble methane monooxygenase which belongs to a class of enzymes known as soluble di-iron monooxygenases. The expression of these enzymes in methanotrophs is often regulated by the availability of copper. The soluble methane monooxygenase has attracted significant attention and has considerable potential in biocatalysis and bioremediation since it can co-oxidize a very wide range of aliphatic and aromatic compounds, even though methanotrophs themselves do not grow on these compounds. We review here the biochemistry and molecular biology of both the particulate and soluble methane monooxygenases and their biotechnological potential.

    Item Type: Book Section
    Additional Information: Part 12
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1007/978-3-540-77587-4_73
    Page Range: 1045-1055
    Depositing User: Users 4 not found.
    Date Deposited: 15 Feb 2011 13:55
    Last Modified: 18 Oct 2018 10:57
    URI: http://shura.shu.ac.uk/id/eprint/3129

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