Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase

Tools

ROWAN, A. S., NICELY, N. I., COCHRANE, N., WLASSOFF, W., CLAIBORNE, A. and HAMILTON, C. J. (2009). Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase. Organic & Biomolecular Chemistry, 7 (19), 4029-4036. [Article]

Abstract
The synthesis of a library of nucleoside triphoshate mimetics is described where the Mg2+ chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhibitors of Bacillus anthracis pantothenate kinase and a competitive inhibitor has been identified with a Ki that is 3-fold lower than the Km value of ATP.
More Information
Research Institute, Centre or Group - Does NOT include content added after October 2018:
Biomedical Research Centre
Page Range:
4029-4036

Identifiers

Identification Number:
10.1039/B909729E

Library

Item Type:
Article
Depositing User:
Users 4 not found.
Date Deposited:
15 Feb 2011 12:31
Last Modified:
19 Mar 2021 00:45
URI:
https://shura.shu.ac.uk/id/eprint/3125
Metrics

Altmetric Badge

Dimensions Badge

Share
Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email

Actions (login required)

View Item View Item

SHURA supports OAI 2.0 with a base URL of https://shura.shu.ac.uk/cgi/oai2