ROWAN, A. S., NICELY, N. I., COCHRANE, N., WLASSOFF, W., CLAIBORNE, A. and HAMILTON, C. J. (2009). Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase. Organic & Biomolecular Chemistry, 7 (19), 4029-4036.Full text not available from this repository.
The synthesis of a library of nucleoside triphoshate mimetics is described where the Mg2+ chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhibitors of Bacillus anthracis pantothenate kinase and a competitive inhibitor has been identified with a Ki that is 3-fold lower than the Km value of ATP.
|Research Institute, Centre or Group:||Biomedical Research Centre|
|Depositing User:||Sarah Ward|
|Date Deposited:||15 Feb 2011 12:31|
|Last Modified:||15 Feb 2011 12:31|
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