Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase

ROWAN, A. S., NICELY, N. I., COCHRANE, N., WLASSOFF, W., CLAIBORNE, A. and HAMILTON, C. J. (2009). Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase. Organic & Biomolecular Chemistry, 7 (19), 4029-4036.

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Link to published version:: 10.1039/B909729E

Abstract

The synthesis of a library of nucleoside triphoshate mimetics is described where the Mg2+ chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhibitors of Bacillus anthracis pantothenate kinase and a competitive inhibitor has been identified with a Ki that is 3-fold lower than the Km value of ATP.

Item Type: Article
Research Institute, Centre or Group: Biomedical Research Centre
Identification Number: 10.1039/B909729E
Depositing User: Sarah Ward
Date Deposited: 15 Feb 2011 12:31
Last Modified: 15 Feb 2011 12:31
URI: http://shura.shu.ac.uk/id/eprint/3125

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