TRAN, William T, SANNACHI, Lakshmanan, PAPANICOLAU, Naum, TADAYYON, Hadi, AL MAHROUKI, Azza, EL KAFFAS, Ahmed, GORJIZADEH, Alborz, LEE, Justin and CZARNOTA, Gregory J (2016). Quantitative ultrasound imaging of therapy response in bladder cancer in vivo. Oncoscience, 3 (3-4), 122-133.
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Official URL: https://www.oncoscience.us/article/302/text/
Abstract
Background and aims
Quantitative ultrasound (QUS) was investigated to monitor bladder cancer treatment response in vivo and to evaluate tumor cell death from combined treatments using ultrasound-stimulated microbubbles and radiation therapy.Methods
Tumor-bearing mice (n=45), with bladder cancer xenografts (HT- 1376) were exposed to 9 treatment conditions consisting of variable concentrations of ultrasound-stimulated Definity microbubbles [nil, low (1%), high (3%)], combined with single fractionated doses of radiation (0 Gy, 2 Gy, 8 Gy). High frequency (25 MHz) ultrasound was used to collect the raw radiofrequency (RF) data of the backscatter signal from tumors prior to, and 24 hours after treatment in order to obtain QUS parameters. The calculated QUS spectral parameters included the mid-band fit (MBF), and 0-MHz intercept (SI) using a linear regression analysis of the normalized power spectrum.Results and conclusions
There were maximal increases in QUS parameters following treatments with high concentration microbubbles combined with 8 Gy radiation: (ΔMBF = +6.41 ± 1.40 (±SD) dBr and SI= + 7.01 ± 1.20 (±SD) dBr. Histological data revealed increased cell death, and a reduction in nuclear size with treatments, which was mirrored by changes in quantitative ultrasound parameters. QUS demonstrated markers to detect treatment effects in bladder tumors in vivo.Item Type: | Article |
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Uncontrolled Keywords: | quantitative ultrasound; radiation therapy; ultrasound; vascular disrupting agents |
Identification Number: | https://doi.org/10.18632/oncoscience.302 |
Page Range: | 122-133 |
SWORD Depositor: | Symplectic Elements |
Depositing User: | Symplectic Elements |
Date Deposited: | 26 Apr 2023 09:50 |
Last Modified: | 26 Apr 2023 09:50 |
URI: | https://shura.shu.ac.uk/id/eprint/30951 |
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