Identification of the Involvement of Potassium Channels in Fibromyalgia

LAWSON, Kim (2022). Identification of the Involvement of Potassium Channels in Fibromyalgia. Frontiers in Bioscience-Scholar, 14 (4): 29.

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Official URL: https://www.imrpress.com/journal/FBS/14/4/10.31083...
Open Access URL: https://doi.org/10.31083/j.fbs1404029 (Published version)
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    Abstract

    Fibromyalgia is a central sensitivity syndrome that presents with chronic pain, fatigue, cognitive dysfunction, and disordered sleep. The pathophysiology which due to multisensory hypersensitivity of the central nervous system involves neuronal excitability leading to central sensitization. Treatments of the challenges associated with the complexities of fibromyalgia involve combinations of pharmacological and non-pharmacological therapeutic approaches which often offer limited benefit. Potassium (K+) channels play a fundamental role in establishing and maintaining stability of neuronal activity. The large molecular diversity and distribution of K+ channels support involvement in a broad range of physiological functions. In nociceptive pathways, neuronal hyperexcitability leading to pain sensation has been associated with reduced function of K+ channels and loss of cellular control. This article reviews the evidence of involvement of K+ channels in fibromyalgia. A potential role both in the pathophysiological processes responsible for the symptoms of fibromyalgia and as therapeutic targets for the management of the condition is considered.

    Item Type: Article
    Identification Number: https://doi.org/10.31083/j.fbs1404029
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 25 Oct 2022 15:19
    Last Modified: 25 Oct 2022 15:19
    URI: https://shura.shu.ac.uk/id/eprint/30940

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