The cancer stem cell potency of group 10‐Azadiphosphine metal complexes

XIAO, Zhiyin, NORTHCOTE‐SMITH, Joshua, JOHNSON, Alice, SINGH, Kuldip and SUNTHARALINGAM, Kogularamanan (2022). The cancer stem cell potency of group 10‐Azadiphosphine metal complexes. European Journal of Inorganic Chemistry.

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Link to published version:: https://doi.org/10.1002/ejic.202200427
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    Abstract

    Abstract: The cancer stem cell (CSC) potency of a series of structurally analogous Group 10‐azadiphosphine metal complexes is reported. The complexes comprise a Group 10 metal (Ni for 1, Pd for 2, or Pt for 3), an azadiphosphine ligand, and two chloride ligands. The complexes exhibit micromolar potency towards bulk breast cancer cells and breast CSCs cultured in monolayer systems. The cytotoxicity of the complexes is comparable to or better than clinically used metallopharmaceuticals, cisplatin and carboplatin, and the gold‐standard anti‐breast CSC agent, salinomycin. Notably, the breast CSC mammosphere inhibitory effect and potency of the complexes is dependent on the Group 10 metal present, increasing in the following order: 3<2<1. This study highlights the importance of the metal within a given series of structurally related compounds to their breast CSC mammosphere activity and reinforces the therapeutic potential of Group 10 coordination complexes as anti‐CSC agents.

    Item Type: Article
    Additional Information: ** Article version: VoR ** From Wiley via Jisc Publications Router ** Licence for VoR version of this article: http://creativecommons.org/licenses/by/4.0/ **Journal IDs: issn 1434-1948; issn 1099-0682 **Article IDs: publisher-id: ejic202200427 **History: published 26-08-2022; rev-recd 01-08-2022; submitted 04-07-2022
    Uncontrolled Keywords: Research Article, Research Articles, Antitumour agents, Cancer stem cells, Group 10 compounds, Transition metals, Mammosphere studies
    Identification Number: https://doi.org/10.1002/ejic.202200427
    SWORD Depositor: Colin Knott
    Depositing User: Colin Knott
    Date Deposited: 31 Aug 2022 12:29
    Last Modified: 31 Aug 2022 12:29
    URI: http://shura.shu.ac.uk/id/eprint/30641

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