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DANAT, Isaac, CLIFFORD, Angela, PARTRIDGE, Martin, ZHOU, Weiju, BAKRE, Aishat T, CHEN, Anthony, MCFEETERS, Danielle, SMITH, Tina, WAN, Yuhui, COPELAND, John, ANSTEY, Kaarin J and CHEN, Ruoling (2019). Impacts of Overweight and Obesity in Older Age on the Risk of Dementia: A Systematic Literature Review and a Meta-Analysis. Journal of Alzheimer's Disease, 70 (s1), S87-S99.
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Abstract
Background: It is unclear whether overweight and obesity in older age reduces or increases the risk of incident dementia. Objective: To assess the impacts of overweight and obesity in older age on incident dementia. Methods: We searched cohort studies reporting body weight measured in older age and dementia through PubMed, Embase, Medline, PyschInfo, and Cochrane library until July 2016. Sixteen articles were identified for the review. We pooled data from them and a new unpublished study from China, to calculate relative risk (RR) of incident dementia in relation to body mass index (BMI) and waist circumference (WC). Results: All 16 cohort studies were undertaken in high income countries, with follow-up periods ranging between 3 to 18 years. Thirteen studies showed an inverse association between BMI and dementia, and three studies demonstrated a positive association. Pooled RR of dementia in relation to continuous BMI from 14 studied populations, including the new Chinese data, was 0.97 (95%CI 0.95–1.00); in those followed up <9 years it was 0.95 (0.93–0.96) while in ≥9 years follow-up it was 1.03 (0.96–1.11). In five studied populations examining categorical BMI, RR of dementia in older people classified as overweight and obese was 0.98 (0.54–1.77) and 1.17 (0.65–2.10) respectively, in comparison with other weights. The pooled WC data showed no association between increased WC and reduced risk of dementia. Conclusion: The current evidence did not support a paradox on beneficial impacts of overweight and obesity in older age on incident dementia. More studies with long term follow up are needed to clarify the association of body weight in older age with dementia risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Neurology & Neurosurgery; 1103 Clinical Sciences; 1109 Neurosciences; 1702 Cognitive Sciences |
| Identification Number: | https://doi.org/10.3233/jad-180763 |
| Page Range: | S87-S99 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 13 Sep 2022 18:48 |
| Last Modified: | 12 Oct 2023 10:16 |
| URI: | https://shura.shu.ac.uk/id/eprint/30418 |
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