Impacts of Overweight and Obesity in Older Age on the Risk of Dementia: A Systematic Literature Review and a Meta-Analysis

DANAT, Isaac, CLIFFORD, Angela, PARTRIDGE, Martin, ZHOU, Weiju, BAKRE, Aishat T, CHEN, Anthony, MCFEETERS, Danielle, SMITH, Tina, WAN, Yuhui, COPELAND, John, ANSTEY, Kaarin J and CHEN, Ruoling (2019). Impacts of Overweight and Obesity in Older Age on the Risk of Dementia: A Systematic Literature Review and a Meta-Analysis. Journal of Alzheimer's Disease, 70 (s1), S87-S99.

[img]
Preview
PDF
Danat-ImpactsOfOverweightAndObesity(VoR).pdf - Published Version
Creative Commons Attribution Non-commercial.

Download (565kB) | Preview
Official URL: https://content.iospress.com/articles/journal-of-a...
Open Access URL: https://content.iospress.com/download/journal-of-a... (Published)
Link to published version:: https://doi.org/10.3233/jad-180763
Related URLs:

    Abstract

    Background: It is unclear whether overweight and obesity in older age reduces or increases the risk of incident dementia. Objective: To assess the impacts of overweight and obesity in older age on incident dementia. Methods: We searched cohort studies reporting body weight measured in older age and dementia through PubMed, Embase, Medline, PyschInfo, and Cochrane library until July 2016. Sixteen articles were identified for the review. We pooled data from them and a new unpublished study from China, to calculate relative risk (RR) of incident dementia in relation to body mass index (BMI) and waist circumference (WC). Results: All 16 cohort studies were undertaken in high income countries, with follow-up periods ranging between 3 to 18 years. Thirteen studies showed an inverse association between BMI and dementia, and three studies demonstrated a positive association. Pooled RR of dementia in relation to continuous BMI from 14 studied populations, including the new Chinese data, was 0.97 (95%CI 0.95–1.00); in those followed up <9 years it was 0.95 (0.93–0.96) while in ≥9 years follow-up it was 1.03 (0.96–1.11). In five studied populations examining categorical BMI, RR of dementia in older people classified as overweight and obese was 0.98 (0.54–1.77) and 1.17 (0.65–2.10) respectively, in comparison with other weights. The pooled WC data showed no association between increased WC and reduced risk of dementia. Conclusion: The current evidence did not support a paradox on beneficial impacts of overweight and obesity in older age on incident dementia. More studies with long term follow up are needed to clarify the association of body weight in older age with dementia risk.

    Item Type: Article
    Uncontrolled Keywords: Neurology & Neurosurgery; 1103 Clinical Sciences; 1109 Neurosciences; 1702 Cognitive Sciences
    Identification Number: https://doi.org/10.3233/jad-180763
    Page Range: S87-S99
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 13 Sep 2022 18:48
    Last Modified: 13 Sep 2022 18:48
    URI: http://shura.shu.ac.uk/id/eprint/30418

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics