Supervised aerobic exercise training and increased lifestyle physical activity to reduce cardiovascular disease risk for women with polycystic ovary syndrome: a randomized controlled feasibility trial

WOODWARD, Amie, BROOM, David, DALTON, Caroline, METWALLY, Mostafa and KLONIZAKIS, Markos (2022). Supervised aerobic exercise training and increased lifestyle physical activity to reduce cardiovascular disease risk for women with polycystic ovary syndrome: a randomized controlled feasibility trial. Journal of Physical Activity & Health, 19 (6), 436-445.

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Link to published version:: https://doi.org/10.1123/jpah.2022-0103
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    Abstract

    Background: Polycystic ovary syndrome (PCOS) is a complex, heterogeneous endocrinopathy. Women with PCOS often present with cardiovascular disease risk factors. Physical activity (PA) interventions reduce cardiovascular disease risk factors in women with PCOS. However, sedentary behaviors have a distinct deleterious effect on cardiometabolic health. Increasing PA and reducing sedentary behaviors may be a worthwhile therapeutic target to improve cardiovascular health in this population. This study investigated the feasibility of 2 PA interventions to decrease cardiovascular disease risk in women with PCOS. Methods: This was a feasibility randomized controlled trial of 2 PA interventions in 36 women with PCOS. Participants were randomized to a supervised exercise intervention (n = 12), a lifestyle physical activity group intervention aimed at reducing sedentary behaviors (n = 12), or a control group (n = 12), for 12 weeks. Primary outcomes included the feasibility and acceptability of the interventions and procedures. Results: Recruitment rate was 56%. Adherence rate was 53% and 100% to the exercise intervention and lifestyle PA intervention, respectively. Secondary outcome data indicate a reduction in oxidized low-density lipoprotein concentrations in the exercise group, and weight loss in both intervention groups. Conclusions: The procedures for recruitment, allocation, and outcome measurements were acceptable. However, before progression to a full-scale trial, adherence to the exercise program should be addressed.

    Item Type: Article
    Additional Information: Accepted author manuscript version reprinted, by permission, from Journal of Physical Activity and Health, 2022, volume 19 (issue 6): 436-445, https://doi.org/10.1123/jpah.2022-0103. © Human Kinetics, Inc.
    Identification Number: https://doi.org/10.1123/jpah.2022-0103
    Page Range: 436-445
    Depositing User: Colin Knott
    Date Deposited: 06 Jun 2022 15:35
    Last Modified: 07 Jun 2022 12:09
    URI: http://shura.shu.ac.uk/id/eprint/30291

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