A tri-metallic palladium complex with breast cancer stem cell potency

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ESKANDARI, A, KUNDU, A, JOHNSON, Alice, KARMAKAR, S, GHOSH, S and SUNTHARALINGAM, K (2020). A tri-metallic palladium complex with breast cancer stem cell potency. Dalton Transactions, 49 (14), 4211-4215. [Article]

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Abstract

A multi-nuclear, triangular-shaped palladium(ii) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(ii) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.

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Official URL:

https://pubs.rsc.org/en/content/articlelanding/202...

Uncontrolled Keywords:

Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Neoplastic Stem Cells; Palladium; Cell Line, Tumor; Humans; Breast Neoplasms; DNA Damage; Palladium; DNA, Neoplasm; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Apoptosis; Cell Proliferation; Molecular Structure; Models, Molecular; Female; Neoplastic Stem Cells; Coordination Complexes; HEK293 Cells; Inorganic & Nuclear Chemistry; 0302 Inorganic Chemistry; 0307 Theoretical and Computational Chemistry; 0399 Other Chemical Sciences

Page Range:

4211-4215

Event Location:

England

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Identification Number:

10.1039/d0dt00006j

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Item Type:

Article

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Symplectic Elements