A tri-metallic palladium complex with breast cancer stem cell potency

ESKANDARI, A, KUNDU, A, JOHNSON, Alice, KARMAKAR, S, GHOSH, S and SUNTHARALINGAM, K (2020). A tri-metallic palladium complex with breast cancer stem cell potency. Dalton Transactions, 49 (14), 4211-4215.

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Official URL: https://pubs.rsc.org/en/content/articlelanding/202...
Link to published version:: https://doi.org/10.1039/d0dt00006j


A multi-nuclear, triangular-shaped palladium(ii) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(ii) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.

Item Type: Article
Uncontrolled Keywords: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Neoplastic Stem Cells; Palladium; Cell Line, Tumor; Humans; Breast Neoplasms; DNA Damage; Palladium; DNA, Neoplasm; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Apoptosis; Cell Proliferation; Molecular Structure; Models, Molecular; Female; Neoplastic Stem Cells; Coordination Complexes; HEK293 Cells; Inorganic & Nuclear Chemistry; 0302 Inorganic Chemistry; 0307 Theoretical and Computational Chemistry; 0399 Other Chemical Sciences
Identification Number: https://doi.org/10.1039/d0dt00006j
Page Range: 4211-4215
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 13 May 2022 16:08
Last Modified: 12 Oct 2023 12:15
URI: https://shura.shu.ac.uk/id/eprint/30019

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