Gluten sensitivity: from gut to brain

HADJIVASSILIOU, M., SANDERS, D. S., GRUNEWALD, R. A., WOODROOFE, N., BOSCOLO, S. and AESCHLIMANN, D. (2010). Gluten sensitivity: from gut to brain. The Lancet Neurology, 9 (3), 318-330.

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Link to published version:: 10.1016/S1474-4422(09)70290-X

Abstract

Gluten sensitivity is a systemic autoimmune disease with diverse manifestations. This disorder is characterised by abnormal immunological responsiveness to ingested gluten in genetically susceptible individuals. Coeliac disease, or gluten-sensitive enteropathy, is only one aspect of a range of possible manifestations of gluten sensitivity. Although neurological manifestations in patients with established coeliac disease have been reported since 1966, it was not until 30 years later that, in some individuals, gluten sensitivity was shown to manifest solely with neurological dysfunction. Furthermore, the concept of extraintestinal presentations without enteropathy has only recently become accepted. In this Personal View, we review the range of neurological manifestations of gluten sensitivity and discuss recent advances in the diagnosis and understanding of the pathophysiological mechanisms underlying neurological dysfunction related to gluten sensitivity.

Item Type: Article
Research Institute, Centre or Group: Biomedical Research Centre
Identification Number: 10.1016/S1474-4422(09)70290-X
Depositing User: Sarah Ward
Date Deposited: 19 Jan 2011 16:41
Last Modified: 19 Jan 2011 16:41
URI: http://shura.shu.ac.uk/id/eprint/2985

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