Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery

SKESTERS, A., KUSTOVS, D., LECE, A., MOREINO, E., PETROSINA, E. and RAINSFORD, Kim (2022). Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery. Inflammopharmacology, 30 (2), 499-503.

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Official URL: https://link.springer.com/article/10.1007/s10787-0...
Open Access URL: https://link.springer.com/content/pdf/10.1007/s107... (Published version)
Link to published version:: https://doi.org/10.1007/s10787-022-00925-z
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    Abstract

    Background: This study aimed to assess tendency of oxidative stress in COVID-19 patients depending on severity. Methods: The study was conducted with 80 post-COVID-19 disease patients and 40 acutely ill patients. Content of selenium in blood plasma was detected by a fluorimetric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P, malondialdehyde and 4-hydroxynonenal and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results: Obtained results showed that selenium content in blood for post-COVID-19 disease patients was of a similar lower norm for Latvian inhabitants. Selenium and seleno-protein P contents for acute patients were significantly decreased compared with post-COVID-19 disease patients. Conclusion: In conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body.

    Item Type: Article
    Uncontrolled Keywords: Pharmacology & Pharmacy; 1115 Pharmacology and Pharmaceutical Sciences
    Identification Number: https://doi.org/10.1007/s10787-022-00925-z
    Page Range: 499-503
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 08 Mar 2022 14:54
    Last Modified: 05 Apr 2022 15:00
    URI: http://shura.shu.ac.uk/id/eprint/29849

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