Study protocol: A randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina.

BOURKE, Liam, TEW, Garry, MILO, M, CROSSMAN, DC, SAXTON, JM and CHICO, TJA (2010). Study protocol: A randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina. BMC Public Health, 10, p. 620.

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Official URL: http://www.biomedcentral.com/bmcpublichealth/
Link to published version:: https://doi.org/10.1186/1471-2458-10-620
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    Abstract

    Background Exercise training has been shown to reduce angina and promote collateral vessel development in patients with coronary artery disease. However, the mechanism whereby exercise exerts these beneficial effects is unclear. There has been increasing interest in the use of whole genome peripheral blood gene expression in a wide range of conditions to attempt to identify both novel mechanisms of disease and transcriptional biomarkers. This protocol describes a study in which we will assess the effect of a structured exercise programme on peripheral blood gene expression in patients with stable angina, and correlate this with changes in angina level, anxiety, depression, and exercise capacity. Methods/Design Sixty patients with stable angina will be recruited and randomised 1:1 to exercise training or conventional care. Patients randomised to exercise training will attend an exercise physiology laboratory up to three times weekly for supervised aerobic interval training sessions of one hour in total duration. Patients will undergo assessments of angina, anxiety, depression, and peripheral blood gene expression at baseline, after six and twelve weeks of training, and twelve weeks after formal exercise training ceases. Discussion This study will provide comprehensive data on the effect of exercise training on peripheral blood gene expression in patients with angina. By correlating this with improvement in angina status we will identify candidate peripheral blood transcriptional markers predictive of improvements in angina level in response to exercise training. Trial Registration Clinicaltrials.gov identifier: NCT01147952

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Centre for Sport and Exercise Science
    Identification Number: https://doi.org/10.1186/1471-2458-10-620
    Page Range: p. 620
    Depositing User: Rachel Davison
    Date Deposited: 27 Jan 2011 13:26
    Last Modified: 26 May 2017 08:50
    URI: http://shura.shu.ac.uk/id/eprint/2964

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