Impact of carbon monoxide on early cardiac development in an avian model

ROMBO MATIAS, Filipa, GROVES, Ian and HERIGSTAD, Mari (2021). Impact of carbon monoxide on early cardiac development in an avian model. [Pre-print] (Unpublished)

Preprints have not been peer-reviewed. They should not be relied on to guide clinical practice or health related behaviour and should not be regarded as conclusive or be reported in news media as established information.
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Official URL: https://www.biorxiv.org/content/10.1101/2021.12.22...
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    Abstract

    Carbon monoxide (CO) is a toxic gas that can be lethal in large doses and may also cause physiological damage in lower doses. Epidemiological studies suggest that CO in lower doses over time may impact on embryo development, in particular cardiac development, however other studies have not observed this association. Here, we exposed chick embryos in ovo to CO at three different concentrations (1ppm, 8ppm, 25ppm) plus air control (4 protocols in total) for the first nine days of development, at which point we assessed egg and embryo weight, ankle length, developmental stage, heart weight and ventricular wall thickness. We found that heart weight was reduced for the low and moderate exposures compared to air, and that ventricular wall thickness was increased for the moderate and high exposures compared to air. Ventricular wall thickness was also significantly positively correlated with absolute CO exposures across all protocols. This intervention study thus suggests that CO even at very low levels may have a significant impact on cardiac development.

    Item Type: Pre-print
    Identification Number: https://doi.org/10.1101/2021.12.22.473783
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 27 Jan 2022 14:56
    Last Modified: 11 Feb 2022 10:45
    URI: https://shura.shu.ac.uk/id/eprint/29502

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