Cell sources proposed for nucleus pulposus regeneration

WILLIAMS, Rebecca J., TRYFONIDOU, Marianna A., SNUGGS, Joseph Wiliam and LE MAITRE, Christine Lyn (2021). Cell sources proposed for nucleus pulposus regeneration. JOR Spine.

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Official URL: https://onlinelibrary.wiley.com/doi/10.1002/jsp2.1...
Open Access URL: https://onlinelibrary.wiley.com/doi/epdf/10.1002/j... (Published version)
Link to published version:: https://doi.org/10.1002/jsp2.1175
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    Abstract

    Abstract: Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD). The current treatments for chronic back pain only provide alleviation of symptoms through pain relief, tissue removal, or spinal fusion; none of which target regenerating the degenerate IVD. As nucleus pulposus (NP) degeneration is thought to represent a key initiation site of IVD degeneration, cell therapy that specifically targets the restoration of the NP has been reviewed here. A literature search to quantitatively assess all cell types used in NP regeneration was undertaken. With key cell sources: NP cells; annulus fibrosus cells; notochordal cells; chondrocytes; bone marrow mesenchymal stromal cells; adipose‐derived stromal cells; and induced pluripotent stem cells extensively analyzed for their regenerative potential of the NP. This review highlights: accessibility; expansion capability in vitro; cell survival in an IVD environment; regenerative potential; and safety for these key potential cell sources. In conclusion, while several potential cell sources have been proposed, iPSC may provide the most promising regenerative potential.

    Item Type: Article
    Additional Information: ** Article version: VoR ** From Wiley via Jisc Publications Router ** Licence for VoR version of this article: http://creativecommons.org/licenses/by-nc-nd/4.0/ **Journal IDs: issn 2572-1143 **Article IDs: publisher-id: jsp21175 **History: published 24-11-2021; accepted 20-10-2021; rev-recd 01-10-2021; submitted 29-07-2021
    Uncontrolled Keywords: REVIEW, REVIEWS, biologic therapies, regenerative medicine, stem cell, tissue engineering
    Identification Number: https://doi.org/10.1002/jsp2.1175
    SWORD Depositor: Colin Knott
    Depositing User: Colin Knott
    Date Deposited: 25 Nov 2021 11:25
    Last Modified: 25 Nov 2021 11:30
    URI: http://shura.shu.ac.uk/id/eprint/29371

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