Synthesis and In Vitro Anti-Helicobacter and Anti-Staphylococcal Activities of Novel Diaryldisulfides and Diarylthiosulfonates

KHAN, Muhammad, MILLER, Keith, RAWSON, Kirstie and ZHOU, Yong (2021). Synthesis and In Vitro Anti-Helicobacter and Anti-Staphylococcal Activities of Novel Diaryldisulfides and Diarylthiosulfonates. Advances in Biological Chemistry, 11 (5), 251-265.

[img]
Preview
PDF
abc_2021102814314325.pdf - Published Version
Creative Commons Attribution.

Download (1MB) | Preview
Official URL: https://www.scirp.org/journal/paperinformation.asp...
Open Access URL: https://www.scirp.org/pdf/abc_2021102814314325.pdf (Published)
Link to published version:: https://doi.org/10.4236/abc.2021.115017
Related URLs:

    Abstract

    Arylthiols were reacted with acrylonitrile under basic conditions to form the corresponding aryl sulfides which were oxidised with sodium metaperiodate in aqueous methanol to yield 3-arylsulphinylpropanenitriles that upon thermolysis in refluxing toluene produced a mixture of diarylthiosulfonates and diaryldisulfides. The mixture of the two products was easily separated by flash chromatography and characterized spectroscopically. The diarylthiosulfonates and diaryldisulfides, garlic-like organosulfur compounds, were tested for their antimicrobial properties against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Helicobacter pylori and had been found to have good activity against S. aureas and H. pylori with no activity against the other two organisms.

    Item Type: Article
    Identification Number: https://doi.org/10.4236/abc.2021.115017
    Page Range: 251-265
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 09 Nov 2021 17:13
    Last Modified: 09 Nov 2021 17:15
    URI: http://shura.shu.ac.uk/id/eprint/29307

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics