Aspirin use for cancer prevention: a systematic review of public, patient and healthcare provider attitudes and adherence behaviours

LLOYD, Kelly, HALL, Louise, KING, Natalie, THORNELOE, Rachael, RODRIGUEZ-LOPEZ, Rocio, ZIEGLER, Lucy, TAYLOR, David, MACKENZIE, Mairead and SMITH, Samuel (2021). Aspirin use for cancer prevention: a systematic review of public, patient and healthcare provider attitudes and adherence behaviours. Preventive Medicine, 154, p. 106872.

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Link to published version:: https://doi.org/10.1016/j.ypmed.2021.106872
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    Abstract

    We undertook a systematic review to synthesise the data on attitudes and behaviour towards the use of aspirin for cancer prevention, and healthcare providers' attitudes towards implementing aspirin in practice. Searches were carried out across 12 databases (e.g. MEDLINE, EMBASE). We used the Mixed Methods Appraisal Tool to evaluate study quality, and conducted a narrative synthesis of the data. The review was pre-registered (PROSPERO: CRD42018093453). Thirty-eight studies were identified. Uptake and adherence data were all from trials. Trials recruited healthy participants, those at higher risk of cancer, and those with cancer. Four studies reported moderate to high (40.9–77.7%) uptake to an aspirin trial among people who were eligible. Most trials (18/22) reported high day-to-day adherence (≥80%). Three trials observed no association between gender and adherence. One trial found no association between adherence and colorectal cancer risk. Three studies reported moderate to high (43.6–76.0%) hypothetical willingness to use aspirin. Two studies found that a high proportion of healthcare providers (72.0–76.0%) perceived aspirin to be a suitable cancer prevention option. No qualitative studies were identified. The likelihood that eligible users of aspirin would participate in a trial evaluating the use of aspirin for preventive therapy was moderate to high. Among participants in a trial, day-to-day adherence was high. Further research is needed to identify uptake and adherence rates in routine care, the factors affecting aspirin use, and the barriers to implementing aspirin into clinical care.

    Item Type: Article
    Uncontrolled Keywords: Public Health; 1106 Human Movement and Sports Sciences; 1117 Public Health and Health Services
    Identification Number: https://doi.org/10.1016/j.ypmed.2021.106872
    Page Range: p. 106872
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 05 Nov 2021 12:49
    Last Modified: 23 Nov 2021 11:00
    URI: http://shura.shu.ac.uk/id/eprint/29284

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