Tools
Tools
MAWSON, S, KEEN, C, SKILBECK, Julie, ROSS, H, SMITH, L, DIXEY, J, WALTERS, SJ, SIMPSON, R, GREENFIELD, DM and SNOWDEN, JA (2021). Feasibility and benefits of a structured prehabilitation programme prior to autologous stem cell transplantation (ASCT) in patients with myeloma; a prospective feasibility study. Physiotherapy, 113, 88-99.
|
PDF
Skilbeck-FeasibilityBenefitsStructuredPrehabilitation(VoR).pdf - Published Version Creative Commons Attribution Non-commercial No Derivatives. Download (483kB) | Preview |
Abstract
Evidence supports the benefits of exercise-based rehabilitation in promoting recovery in myeloma patients following autologous stem-cell transplantation (ASCT). However, ‘prehabilitation’ has never been evaluated prior to ASCT, despite evidence of effectiveness in other cancers. Utilising a mixed method approach the authors investigated the feasibility of a mixed strength and cardiovascular exercise intervention pre-ASCT. Quantitative data were collected to determine feasibility targets; rates of recruitment, adherence and adverse events, including 6 minute walking distance (6MWD) test and patient reported outcome measures (PROMs). Qualitative interviews were undertaken with a purposive sample of patients to capture their experiences of the study and the intervention. The authors recruited 23 patients who attended a mean percentage of 75% scheduled exercise sessions. However, retention rates were limited, with only 14/23 (62%) completing the programme. In these patients, the 6MWD increased from a mean of 346 to 451 m (i.e. by 105 m, 95% CI 62 to 148 m) with no serious adverse events. Whist participants found the exercise programme acceptable and reported improvement in their physical fitness and overall mental health and wellbeing prior to ASCT, the study identified challenges in hospital attendance for the prehabilitation schedule whilst receiving induction or re-induction chemotherapy. Evaluation of digitally-enhanced directed but remote prehabilitation models for this patient group is warranted. Trial registration number NCT03135925
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Autologous stem-cell transplantation; Exercise-based rehabilitation; PROMs; Prehabilitation; Rehabilitation; 1103 Clinical Sciences; 1106 Human Movement and Sports Sciences; 1199 Other Medical and Health Sciences |
| Identification Number: | https://doi.org/10.1016/j.physio.2021.08.001 |
| Page Range: | 88-99 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 05 Oct 2021 10:23 |
| Last Modified: | 05 Oct 2021 10:30 |
| URI: | https://shura.shu.ac.uk/id/eprint/29127 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year