Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence

IAMJAN, Sri-arun, THANOI, Samur, WATIKTINKORN, Paritat, FACHIM, Helene, DALTON, Caroline, NUDMAMUD-THANOI, Sutisa and REYNOLDS, Gavin (2021). Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence. Epigenomics, 13 (12), 953-965.

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    Abstract

    Aim: We investigated DNA methylation of BDNF in methamphetamine (METH) dependence in humans and an animal model. Materials & methods: BDNF methylation at exon IV was determined by pyrosequencing of blood DNA from METH-dependent and control subjects, and from rat brain following an escalating dose of METH or vehicle. Bdnf expression was determined in rat brain. Results: BDNF methylation was increased in human METH dependence, greatest in subjects with psychosis and in prefrontal cortex of METH-administered rats; rat hippocampus showed reduced Bdnf methylation and increased gene expression. Conclusion: BDNF methylation is abnormal in human METH dependence, especially METH-dependent psychosis, and in METH-administered rats. This may influence BDNF expression and contribute to the neurotoxic effects of METH exposure.

    Item Type: Article
    Additional Information: ** Embargo end date: 19-05-2022 ** From Future Science Group via Jisc Publications Router **Journal IDs: pissn 1750-1911; eissn 1750-192X **History: online 19-05-2021; published 19-05-2021; published 05-2021; accepted 29-04-2021; submitted 29-12-2020 **License for this article: starting on 19-05-2022, , https://www.future-science-group.com/archiving
    Uncontrolled Keywords: Research Article, BDNF, DNA methylation, drug dependence, drug-induced psychosis, gene expression, methamphetamine, psychosis, rs6265
    Identification Number: https://doi.org/10.2217/epi-2020-0463
    Page Range: 953-965
    SWORD Depositor: Colin Knott
    Depositing User: Colin Knott
    Date Deposited: 19 May 2021 14:34
    Last Modified: 24 May 2021 09:00
    URI: http://shura.shu.ac.uk/id/eprint/28667

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