IAMJAN, Sri-arun, THANOI, Samur, WATIKTINKORN, Paritat, FACHIM, Helene, DALTON, Caroline, NUDMAMUD-THANOI, Sutisa and REYNOLDS, Gavin (2021). Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence. Epigenomics, 13 (12), 953-965.
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Reynolds-ChangesBDNFExon(AM).pdf - Accepted Version
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Reynolds-ChangesBDNFExon(AM).pdf - Accepted Version
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Abstract
Aim: We investigated DNA methylation of BDNF in methamphetamine (METH) dependence in humans and an animal model. Materials & methods: BDNF methylation at exon IV was determined by pyrosequencing of blood DNA from METH-dependent and control subjects, and from rat brain following an escalating dose of METH or vehicle. Bdnf expression was determined in rat brain. Results: BDNF methylation was increased in human METH dependence, greatest in subjects with psychosis and in prefrontal cortex of METH-administered rats; rat hippocampus showed reduced Bdnf methylation and increased gene expression. Conclusion: BDNF methylation is abnormal in human METH dependence, especially METH-dependent psychosis, and in METH-administered rats. This may influence BDNF expression and contribute to the neurotoxic effects of METH exposure.
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