GABAB Receptors in Neurodegeneration

PRINCIVALLE, Alessandra P. (2021). GABAB Receptors in Neurodegeneration. In: Current Topics in Behavioral Neurosciences. Current Topics in Behavioral Neurosciences . Springer Berlin Heidelberg.

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Link to published version:: https://doi.org/10.1007/7854_2021_222
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    Abstract

    GABA is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and acts via metabotropic GABAB receptors. Neurodegenerative diseases are a major burden and affect an ever increasing number of humans. The actual therapeutic drugs available are partially effective to slow down the progression of the diseases, but there is a clear need to improve pharmacological treatment thus find alternative drug targets and develop newer pharmaco-treatments. This chapter is dedicated to reviewing the latest evidence about GABAB receptors and their inhibitory mechanisms and pathways involved in the neurodegenerative pathologies.

    Item Type: Book Section
    Additional Information: ISSN Online: 1866-3389 ISSN Print : 1866-3370 Invited contribution to a book writing a chapter
    Uncontrolled Keywords: Biomolecular Sciences Research Centre; Alzheimer’s disease; GABAB receptors; Hippocampal sclerosis; Neurodegenerative diseases; Parkinson’s disease; Temporal lobe epilepsy.
    Identification Number: https://doi.org/10.1007/7854_2021_222
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 06 May 2021 15:59
    Last Modified: 12 May 2021 09:45
    URI: http://shura.shu.ac.uk/id/eprint/28618

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