Bacterial manipulation of the Integrated Stress Response: a new perspective on infection

KNOWLES, Alex, CAMPBELL, Susan, CROSS, Neil and STAFFORD, Prachi (2021). Bacterial manipulation of the Integrated Stress Response: a new perspective on infection. Frontiers in Microbiology, 12.

[img]
Preview
PDF
fmicb-12-645161.pdf - Published Version
Creative Commons Attribution.

Download (4MB) | Preview
Official URL: https://www.frontiersin.org/articles/10.3389/fmicb...
Open Access URL: https://www.frontiersin.org/articles/10.3389/fmicb... (Published version)
Link to published version:: https://doi.org/10.3389/fmicb.2021.645161
Related URLs:

    Abstract

    Host immune activation forms a vital line of defence against bacterial pathogenicity. However, just as hosts have evolved immune responses, bacteria have developed means to escape, hijack and subvert these responses to promote survival. In recent years, a highly conserved group of signalling cascades within the host, collectively termed the integrated stress response (ISR), have become increasingly implicated in immune activation during bacterial infection. Activation of the ISR leads to a complex web of cellular reprogramming, which ultimately results in the paradoxical outcomes of either cellular homeostasis or cell death. Therefore, any pathogen with means to manipulate this pathway could induce a range of cellular outcomes and benefit from favourable conditions for long-term survival and replication. This review aims to outline what is currently known about bacterial manipulation of the ISR and present key hypotheses highlighting areas for future research.

    Item Type: Article
    Uncontrolled Keywords: 0502 Environmental Science and Management; 0503 Soil Sciences; 0605 Microbiology
    Identification Number: https://doi.org/10.3389/fmicb.2021.645161
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 26 Apr 2021 14:28
    Last Modified: 11 May 2021 10:15
    URI: http://shura.shu.ac.uk/id/eprint/28552

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics