Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential

ALASWAD, Hamza, MAHBUB, Amani, LE MAITRE, Christine and JORDAN-MAHY, Nikki (2021). Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential. International Journal of Molecular Sciences, 22 (6).

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Open Access URL: https://www.mdpi.com/1422-0067/22/6/3085 (Published version)
Link to published version:: https://doi.org/10.3390/ijms22063085
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    Abstract

    Leukaemia is a malignant disease of the blood. Current treatments for leukaemia are associated with serious side-effects. Plant-derived polyphenols have been identified as potent anti-cancer agents and have been shown to work synergistically with standard chemotherapy agents in leukaemia cell lines. Polyphenols have multiple mechanisms of action and have been reported to decrease cell proliferation, arrest cell cycle and induce apoptosis via the activation of caspase (3, 8 and 9); the loss of mitochondrial membrane potential and the release of cytochrome c. Polyphenols have been shown to suppress activation of transcription factors, including NF-kB and STAT3. Furthermore, polyphenols have pro-oxidant properties, with increasing evidence that polyphenols inhibit the antioxidant activity of glutathione, causing oxidative DNA damage. Polyphenols also induce autophagy-driven cancer cell death and regulate multidrug resistance proteins, and thus may be able to reverse resistance to chemotherapy agents. This review examines the molecular mechanism of action of polyphenols and discusses their potential therapeutic targets. Here, we discuss the pharmacological properties of polyphenols, including their anti-inflammatory, antioxidant, anti-proliferative, and anti-tumour activities, and suggest that polyphenols are potent natural agents that can be useful therapeutically; and discuss why data on bioavailability, toxicity and metabolism are essential to evaluate their clinical use.

    Item Type: Article
    Additional Information: ** From MDPI via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 1422-0067 **History: published 17-03-2021; accepted 10-03-2021
    Uncontrolled Keywords: polyphenols, leukaemia, reactive oxygen species, glutathione, cell cycle, apoptosis, autophagy, multi-drug resistance
    Identification Number: https://doi.org/10.3390/ijms22063085
    SWORD Depositor: Colin Knott
    Depositing User: Colin Knott
    Date Deposited: 22 Mar 2021 11:23
    Last Modified: 30 Mar 2021 12:00
    URI: http://shura.shu.ac.uk/id/eprint/28424

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