The strain-generated electrical potential in cartilaginous tissues: a role for piezoelectricity

POILLOT, P, LE MAITRE, Christine and HUYGHE, J.M. (2021). The strain-generated electrical potential in cartilaginous tissues: a role for piezoelectricity. Biophysical Reviews, 13 (1), 91-100.

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Open Access URL: https://link.springer.com/article/10.1007/s12551-0... (Published version)
Link to published version:: https://doi.org/10.1007/s12551-021-00779-9
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    Abstract

    © 2021, The Author(s). The strain-generated potential (SGP) is a well-established mechanism in cartilaginous tissues whereby mechanical forces generate electrical potentials. In articular cartilage (AC) and the intervertebral disc (IVD), studies on the SGP have focused on fluid- and ionic-driven effects, namely Donnan, diffusion and streaming potentials. However, recent evidence has indicated a direct coupling between strain and electrical potential. Piezoelectricity is one such mechanism whereby deformation of most biological structures, like collagen, can directly generate an electrical potential. In this review, the SGP in AC and the IVD will be revisited in light of piezoelectricity and mechanotransduction. While the evidence base for physiologically significant piezoelectric responses in tissue is lacking, difficulties in quantifying the physiological response and imperfect measurement techniques may have underestimated the property. Hindering our understanding of the SGP further, numerical models to-date have negated ferroelectric effects in the SGP and have utilised classic Donnan theory that, as evidence argues, may be oversimplified. Moreover, changes in the SGP with degeneration due to an altered extracellular matrix (ECM) indicate that the significance of ionic-driven mechanisms may diminish relative to the piezoelectric response. The SGP, and these mechanisms behind it, are finally discussed in relation to the cell response.

    Item Type: Article
    Uncontrolled Keywords: 0299 Other Physical Sciences; 0601 Biochemistry and Cell Biology; 1116 Medical Physiology
    Identification Number: https://doi.org/10.1007/s12551-021-00779-9
    Page Range: 91-100
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 04 Mar 2021 12:54
    Last Modified: 17 Mar 2021 14:00
    URI: http://shura.shu.ac.uk/id/eprint/28306

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