Quantitative ultrasound delta-radiomics during radiotherapy for monitoring treatment responses in head and neck malignancies

TRAN, William, SURAWEERA, Harini, QUIAOIT, Karina, DICENZO, Daniel, FATIMA, Kashuf, JANG, Deok, BHARDWAJ, Divya, KOLIOS, Christopher, KARAM, Irene, POON, Ian, SANNACHI, Lakshmanan, GANGEH, Mehrdad, SADEGHI-NAINI, Ali, DASGUPTA, Archya and CZARNOTA, Gregory J (2020). Quantitative ultrasound delta-radiomics during radiotherapy for monitoring treatment responses in head and neck malignancies. Future Science OA, 6 (9), FSO624.

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Open Access URL: https://www.future-science.com/doi/10.2144/fsoa-20... (Published version)
Link to published version:: https://doi.org/10.2144/fsoa-2020-0073
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    Abstract

    Aim: We investigated quantitative ultrasound (QUS) in patients with node-positive head and neck malignancies for monitoring responses to radical radiotherapy (RT). Materials & methods: QUS spectral and texture parameters were acquired from metastatic lymph nodes 24 h, 1 and 4 weeks after starting RT. K-nearest neighbor and naive-Bayes machine-learning classifiers were used to build prediction models for each time point. Response was detected after 3 months of RT, and patients were classified into complete and partial responders. Results: Single-feature naive-Bayes classification performed best with a prediction accuracy of 80, 86 and 85% at 24 h, week 1 and 4, respectively. Conclusion: QUS-radiomics can predict RT response at 3 months as early as 24 h with reasonable accuracy, which further improves into 1 week of treatment.

    Item Type: Article
    Identification Number: https://doi.org/10.2144/fsoa-2020-0073
    Page Range: FSO624
    SWORD Depositor: Colin Knott
    Depositing User: Colin Knott
    Date Deposited: 07 Sep 2020 12:16
    Last Modified: 04 Nov 2020 11:30
    URI: http://shura.shu.ac.uk/id/eprint/27165

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