Circulating microRNA changes in patients with impaired glucose regulation

FACHIM, H.A., LOUREIRO, C.M., SIDDALS, K., DALTON, Caroline, REYNOLDS, G.P., GIBSON, J.M., CHEN, Z.B. and HEALD, A.H. (2020). Circulating microRNA changes in patients with impaired glucose regulation. Adipocyte, 9 (1), 443-453.

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Open Access URL: https://www.tandfonline.com/doi/full/10.1080/21623... (Published version)
Link to published version:: https://doi.org/10.1080/21623945.2020.1798632
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    Abstract

    © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. We analysed if levels of four miRNAs would change after a lifestyle intervention involving dietary and exercises in prediabetes. MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. mRNA was extracted from fat-tissue for gene expression analyses. The intervention resulted in increased Let-7a and miR-92a. We found correlations between miRNAs and clinical variables (triglycerides, cholesterol, insulin, weight and BMI). We also found correlations between miRNAs and target genes, revealing a link between miR-92a and IGF system. A lifestyle intervention resulted in marked changes in miRNAs. The association of miRNAs with insulin and the IGF system (both receptors and binding proteins) may represent a mechanism of regulating IGFs metabolic actions.

    Item Type: Article
    Uncontrolled Keywords: Circulating microRNAs; prediabetes; impaired glucose regulation (IGR); lifestyle change; Circulating microRNAs; impaired glucose regulation (IGR); lifestyle change; pre-diabetes
    Identification Number: https://doi.org/10.1080/21623945.2020.1798632
    Page Range: 443-453
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 21 Aug 2020 14:29
    Last Modified: 21 Aug 2020 14:30
    URI: http://shura.shu.ac.uk/id/eprint/27018

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