FACHIM, H.A., LOUREIRO, C.M., SIDDALS, K., DALTON, Caroline, REYNOLDS, G.P., GIBSON, J.M., CHEN, Z.B. and HEALD, A.H. (2020). Circulating microRNA changes in patients with impaired glucose regulation. Adipocyte, 9 (1), 443-453.
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Circulating microRNA changes in patients with impaired glucose regulation.pdf - Published Version
Available under License Creative Commons Attribution.
Circulating microRNA changes in patients with impaired glucose regulation.pdf - Published Version
Available under License Creative Commons Attribution.
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Abstract
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. We analysed if levels of four miRNAs would change after a lifestyle intervention involving dietary and exercises in prediabetes. MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. mRNA was extracted from fat-tissue for gene expression analyses. The intervention resulted in increased Let-7a and miR-92a. We found correlations between miRNAs and clinical variables (triglycerides, cholesterol, insulin, weight and BMI). We also found correlations between miRNAs and target genes, revealing a link between miR-92a and IGF system. A lifestyle intervention resulted in marked changes in miRNAs. The association of miRNAs with insulin and the IGF system (both receptors and binding proteins) may represent a mechanism of regulating IGFs metabolic actions.
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