Needles in haystacks: using fast-response LA chambers and ICP-TOF-MS to identify asbestos fibres in malignant mesothelioma models

GREENHALGH, Calum J., VOLOACA, Oana M., SHAW, Phil, DONARD, Ariane, COLE, Laura M., CLENCH, Malcolm R., MANAGH, Amy J. and HAYWOOD-SMALL, Sarah L. (2020). Needles in haystacks: using fast-response LA chambers and ICP-TOF-MS to identify asbestos fibres in malignant mesothelioma models. Journal of Analytical Atomic Spectrometry.

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Open Access URL: https://pubs.rsc.org/en/content/articlehtml/2020/j... (Published version)
Link to published version:: https://doi.org/10.1039/d0ja00268b
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    Abstract

    Malignant mesothelioma is an aggressive cancer associated with exposure to asbestos. Diagnosis of mesothelioma and other related lung diseases remains elusive due to difficulties surrounding identification and quantification of asbestos fibres in lung tissue. This article presents a laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) method to identify asbestos fibres in cellular models of mesothelioma. Use of a high-speed laser ablation system enabled rapid imaging of the samples with a lateral resolution of 3 μm, whilst use of a prototype time-of-flight ICP-MS provided pseudo-simultaneous detection of the elements between mass 23 (Na) and mass 238 (U). Three forms of asbestos fibre (actinolite, amosite and crocidolite) were distinguished from a non-asbestos control (wollastonite) based on their elemental profile, which demonstrated that LA-ICP-MS could be a viable technique for identification of asbestos fibres in clinical research samples.

    Item Type: Article
    Uncontrolled Keywords: Analytical Chemistry; 0301 Analytical Chemistry; 0306 Physical Chemistry (incl. Structural); 0403 Geology
    Identification Number: https://doi.org/10.1039/d0ja00268b
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 17 Aug 2020 15:15
    Last Modified: 17 Aug 2020 15:15
    URI: http://shura.shu.ac.uk/id/eprint/26953

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