Characterization of Biomaterials Intended for Use in the Nucleus Pulposus of Degenerated Intervertebral Discs

SCHMITZ, Tara C., SALZER, Elias, CRISPIM, João F., FABRA, Georgina Targa, LEVISAGE, Catherine, PANDIT, Abhay, TRYFONIDOU, Marianna, MAITRE, Christine Le and ITO, Keita (2020). Characterization of Biomaterials Intended for Use in the Nucleus Pulposus of Degenerated Intervertebral Discs. Acta Biomaterialia, 114, 1-15.

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Open Access URL: https://www.sciencedirect.com/science/article/pii/... (Published version)
Link to published version:: https://doi.org/10.1016/j.actbio.2020.08.001
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    Abstract

    Abstract Biomaterials for regeneration of the intervertebral disc must meet complex requirements conforming to biological, mechanical and clinical demands. Currently no consensus on their characterization exists. It is crucial to identify parameters and their method of characterization for accurate assessment of their potential efficacy, keeping in mind the translation towards clinical application. This review systematically analyzes the characterization techniques of biomaterial systems that have been used for nucleus pulposus (NP) restoration and regeneration. Substantial differences in the approach towards assessment became evident, hindering comparisons between different materials with respect to their suitability for NP restoration and regeneration. We have analyzed the current approaches and identified parameters necessary for adequate biomaterial characterization, with the clinical goal of functional restoration and biological regeneration of the NP in mind. Further, we provide guidelines and goals for their measurement.

    Item Type: Article
    Additional Information: ** Article version: AM ** From Elsevier via Jisc Publications Router ** Licence for AM version of this article starting on 06-08-2020: http://creativecommons.org/licenses/by/4.0/ **Journal IDs: issn 17427061 **History: issue date 07-08-2020; accepted 03-08-2020
    Identification Number: https://doi.org/10.1016/j.actbio.2020.08.001
    Page Range: 1-15
    SWORD Depositor: Colin Knott
    Depositing User: Colin Knott
    Date Deposited: 11 Aug 2020 13:59
    Last Modified: 02 Sep 2020 12:15
    URI: http://shura.shu.ac.uk/id/eprint/26908

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