Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease

LIU, Hanxiang, WEI, Xianwen, YANG, Wen and REYNOLDS, Gavin P. (2020). Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease. Journal of Neural Transmission, 127 (5), 779-783.

[img]
Preview
PDF
702_2019_Article_2119.pdf - Published Version
Creative Commons Attribution.

Download (537kB) | Preview
Link to published version:: https://doi.org/10.1007/s00702-019-02119-4
Related URLs:

    Abstract

    Abstract: Monoamine oxidase type B inhibitors act in Parkinson’s disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is also a feature of environmental toxins, including pesticides, that are an established risk factor for PD. Another risk factor is low circulating uric acid (UA), which may relate to UA being the major endogenous antioxidant in the human body. We have undertaken a study of 192 initial admissions for PD in a general hospital neurology department in a partly rural region of Southern China to determine if there is an increased rate of PD in agricultural workers who have a high risk of exposure to pesticides, and how it may relate to deficits in UA. We found a disproportionately high number of agricultural workers admitted with PD (66.7% vs. 54.3% of all neurology admissions) and that PD subjects have a substantial reduction in UA. This is further reduced in agricultural workers and thus may contribute to the increased vulnerability of this group to PD.

    Item Type: Article
    Additional Information: ** From Springer Nature via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: pissn 0300-9564; eissn 1435-1463 **Article IDs: publisher-id: s00702-019-02119-4; manuscript: 2119 **History: published 05-2020; published_online 14-12-2019; online 14-12-2019; registration 08-12-2019; accepted 08-12-2019; submitted 03-11-2019
    Uncontrolled Keywords: Neurology and Preclinical Neurological Studies - Original Article, Parkinson’s disease, Uric acid, Pesticide exposure, Farming, Oxidative damage, Neurodegeneration
    Identification Number: https://doi.org/10.1007/s00702-019-02119-4
    Page Range: 779-783
    SWORD Depositor: Colin Knott
    Depositing User: Colin Knott
    Date Deposited: 08 Jun 2020 13:50
    Last Modified: 30 Jun 2020 12:16
    URI: http://shura.shu.ac.uk/id/eprint/26420

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics