What is the quality of hydrogel spacer insertions and which patients will benefit A literature review

DRABBLE, J and DRURY-SMITH, Heather (2020). What is the quality of hydrogel spacer insertions and which patients will benefit A literature review. Journal of Radiotherapy in Practice, 1-8.

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Official URL: https://www.cambridge.org/core/journals/journal-of...
Link to published version:: https://doi.org/10.1017/S1460396919000979
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    © 2020 The Author(s). Aim:To evaluate the quality of rectal hydrogel spacer (HS) insertions from literature in patients undergoing radical radiotherapy for prostate cancer. The secondary aim is to assess the benefit of HSs in patients with risk factors more likely to have rectal complications, such as non-conventional radiotherapy dose fractionations and high-risk disease.Method and materials:A literature search of peer-reviewed electronic articles was carried out using Boolean connectors and Medical Subject Headings in the databases. Databases searched included ScienceDirect, Medline and Cinahl. The articles were assessed using relevant critical appraisal skills programme tools.Results:From the 26 studies used, HS showed a clinically significant relative reduction in rectal planning dose volumes for both high- A nd low-risk prostate cancer patients in a range of radiotherapy treatment modalities including volumetric modulated arc therapy, intensity-modulated radiotherapy, intensity-modulated proton therapy, stereotactic ablative body radiotherapy and brachytherapy. Spacer placements were successfully inserted in 99% of patients. However, rectal wall infiltration occurrence was 6% and ≥2 cm unsymmetrical placements in 2%.Findings:A spacer scoring system based on the HS symmetry has provided evidence of the quality of the position inserted, which was visually aided by T2-wieghted MRIs. Despite optimal HS placements ranging from 62 to 72%, HS had a clinically significant reduction of ≥25% in planned rectal V70 dose in 97% of patients.

    Item Type: Article
    Uncontrolled Keywords: Oncology & Carcinogenesis; 1103 Clinical Sciences
    Identification Number: https://doi.org/10.1017/S1460396919000979
    Page Range: 1-8
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 04 Mar 2020 12:27
    Last Modified: 18 Mar 2021 02:33
    URI: http://shura.shu.ac.uk/id/eprint/25932

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