Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans

ILLANGASEKERA, Y.A., KUMARASIRI, P.V.R., FERNANDO, D.J. and DALTON, C.F. (2020). Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans. BMC research notes, 13 (1), p. 34.

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Official URL: https://link.springer.com/article/10.1186/s13104-0...
Link to published version:: https://doi.org/10.1186/s13104-020-4898-4
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    Abstract

    OBJECTIVE: The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated with obesity measures in various ethnicities. We investigated the association of the Q223R polymorphism with obesity related anthropometric measures and biochemical parameters fasting blood glucose and lipid profile in a sample of 530 Sri Lankan adult subjects (age 18-70 years) representing both urban and rural areas of residence. RESULTS: The LEPR Q223R variant G allele frequency was 0.54. The polymorphism was associated with body mass index (p = 0.04) and waist circumference (p = 0.02) measures in overweight and obese (BMI ≥ 25 kgm-2) subjects with the variant allele conferring a greater risk of adiposity. Residency in urban areas eliminated the protective effect of the non-risk genotype (AA) in the development of obesity.

    Item Type: Article
    Uncontrolled Keywords: Genetics; Leptin receptor; Obesity; Polymorphism; Bioinformatics; 1199 Other Medical and Health Sciences; 0601 Biochemistry and Cell Biology
    Identification Number: https://doi.org/10.1186/s13104-020-4898-4
    Page Range: p. 34
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 26 Feb 2020 12:32
    Last Modified: 26 Feb 2020 12:45
    URI: http://shura.shu.ac.uk/id/eprint/25872

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