Breast-Lesion Characterization using Textural Features of Quantitative Ultrasound Parametric Maps

SADEGHI-NAINI, A, SURAWEERA, H, TRAN, WT, HADIZAD, F, BRUNI, G, RASTEGAR, RF, CURPEN, B and CZARNOTA, GJ (2017). Breast-Lesion Characterization using Textural Features of Quantitative Ultrasound Parametric Maps. Scientific Reports, 7 (1), p. 13638.

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Official URL: https://www.nature.com/articles/s41598-017-13977-x
Link to published version:: https://doi.org/10.1038/s41598-017-13977-x
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    Abstract

    © 2017 The Author(s). This study evaluated, for the first time, the efficacy of quantitative ultrasound (QUS) spectral parametric maps in conjunction with texture-analysis techniques to differentiate non-invasively benign versus malignant breast lesions. Ultrasound B-mode images and radiofrequency data were acquired from 78 patients with suspicious breast lesions. QUS spectral-analysis techniques were performed on radiofrequency data to generate parametric maps of mid-band fit, spectral slope, spectral intercept, spacing among scatterers, average scatterer diameter, and average acoustic concentration. Texture-analysis techniques were applied to determine imaging biomarkers consisting of mean, contrast, correlation, energy and homogeneity features of parametric maps. These biomarkers were utilized to classify benign versus malignant lesions with leave-one-patient-out cross-validation. Results were compared to histopathology findings from biopsy specimens and radiology reports on MR images to evaluate the accuracy of technique. Among the biomarkers investigated, one mean-value parameter and 14 textural features demonstrated statistically significant differences (p < 0.05) between the two lesion types. A hybrid biomarker developed using a stepwise feature selection method could classify the legions with a sensitivity of 96%, a specificity of 84%, and an AUC of 0.97. Findings from this study pave the way towards adapting novel QUS-based frameworks for breast cancer screening and rapid diagnosis in clinic.

    Item Type: Article
    Uncontrolled Keywords: 0601 Biochemistry and Cell Biology; 0299 Other Physical Sciences
    Identification Number: https://doi.org/10.1038/s41598-017-13977-x
    Page Range: p. 13638
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 31 Jan 2020 11:32
    Last Modified: 31 Jan 2020 11:45
    URI: http://shura.shu.ac.uk/id/eprint/25708

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