Which simultaneous-integrated boost (SIB) intensity-modulated radiotherapy (IMRT) technique is dosimetrically superior in the treatment of breast cancer; volumetric-modulated arc therapy (VMAT) or fixed field (ff) IMRT?

MURPHY, SBD and DRURY-SMITH, Heather (2017). Which simultaneous-integrated boost (SIB) intensity-modulated radiotherapy (IMRT) technique is dosimetrically superior in the treatment of breast cancer; volumetric-modulated arc therapy (VMAT) or fixed field (ff) IMRT? Journal of Radiotherapy in Practice, 16 (3), 272-279.

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Official URL: https://www.cambridge.org/core/journals/journal-of...
Link to published version:: https://doi.org/10.1017/S1460396917000164
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    Abstract

    Background and purpose To determine which concomitant boost technique is dosimetrically superior in the treatment of breast cancer; volumetric-modulated arc therapy (VMAT) or fixed field intensity-modulated radiotherapy (ff-IMRT). Materials and methods In total, 30 breast patients were re-planned with both VMAT and fixed field concomitant boost intensity-modulated radiotherapy techniques. A hybrid technique was used delivering 80% of the dose through tangential beams and 20% through an integrated boost. A two-tailed t-test sample for means was used to compare the dosimetric differences between the techniques. Results Maximum dose was statistically lower for VMAT; 103 2 versus 103 7% for ff-IMRT along with statistically lower V2 Gy doses to the contralateral lung (0 7 versus 1 6%) and heart for both left- (19 0%/22 6%), and right- (5 5%/8 8%) sided patients, respectively. ff-IMRT boasted significantly lower ipsilateral lung V20, V18 and V10 Gy (7 9/8 6/13 1 versus 8 1/8 8/13 4%) than VMAT, respectively. No differences were found with minimum coverage, mean dose and V5 Gy to all organs at risk (OARs). Conclusion VMAT and ff-IMRT techniques demonstrate excellent target coverage and OAR sparing facilitated by the hybrid planning technique and deep inspiration breath hold. There is no obvious dosimetrically superior option between the two techniques. Reduced treatment times with VMAT make it more desirable to implement clinically.

    Item Type: Article
    Uncontrolled Keywords: breast cancer; dosimetry; IMRT; simultaneous-integrated boost; VMAT; 1103 Clinical Sciences; Oncology & Carcinogenesis
    Identification Number: https://doi.org/10.1017/S1460396917000164
    Page Range: 272-279
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 18 Nov 2019 14:19
    Last Modified: 18 Nov 2019 14:19
    URI: http://shura.shu.ac.uk/id/eprint/25445

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