Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017

FRANK, Tahvi D, CARTER, Austin, JAHAGIRDAR, Deepa, BIEHL, Molly H, DOUWES-SCHULTZ, Dirk, LARSON, Samantha Leigh, ARORA, Megha, DWYER-LINDGREN, Laura, STEUBEN, Krista M, ABBASTABAR, Hedayat, ABU-RADDAD, Laith Jamal, ABYU, Direslgne Misker, ADABI, Maryam, ADEBAYO, Oladimeji M, ADEKANMBI, Victor, ADETOKUNBOH, Olatunji O, AHMADI, Alireza, AHMADI, Keivan, AHMADIAN, Elham, AHMADPOUR, Ehsan, AHMED, Muktar Beshir, AKAL, Chalachew Genet, ALAHDAB, Fares, ALAM, Noore, ALBERTSON, Samuel B, ALEMNEW, Birhan Tamene T, ALENE, Kefyalew Addis, ALIPOUR, Vahid, ALVIS-GUZMAN, Nelson, AMINI, Saeed, ANBARI, Zohreh, ANBER, Nahla Hamed, ANJOMSHOA, Mina, ANTONIO, Carl Abelardo T, ARABLOO, Jalal, AREMU, Olatunde, ARERI, Habtamu Abera, ASFAW, Ephrem Tsegay, ASHAGRE, Alebachew Fasil, ASMELASH, Daniel, ASRAT, Anemaw A, AVOKPAHO, Euripide FGA, AWASTHI, Ashish, AWOKE, Nefsu, AYANORE, Martin Amogre, AZARI, Samad, BADAWI, Alaa, BAGHERZADEH, Mojtaba, BANACH, Maciej, BARAC, Aleksandra, BÄRNIGHAUSEN, Till Winfried, BASU, Sanjay, BEDI, Neeraj, BEHZADIFAR, Masoud, BEKELE, Bayu Begashaw, BELAY, Saba Abraham, BELAY, Yared Belete, BELAYNEH, Yaschilal Muche, BERHANE, Adugnaw, BHAT, Anusha Ganapati, BHATTACHARYYA, Krittika, BIADGO, Belete, BIJANI, Ali, BIN SAYEED, Muhammad Shahdaat, BITEW, Helen, BLINOV, Andrew, BOGALE, Kassawmar Angaw, BOJIA, Hunduma Amensisa, BURUGINA NAGARAJA, Sharath BN, BUTT, Zahid A, CAHUANA-HURTADO, Lucero, CAMPUZANO RINCON, Julio Cesar, CARVALHO, Félix, CHATTU, Vijay Kumar, CHRISTOPHER, Devasahayam J, CHU, Dinh-Toi, CRIDER, Raquel, DAHIRU, Tukur, DANDONA, Lalit, DANDONA, Rakhi, DARYANI, Ahmad, DAS NEVES, José, DE NEVE, Jan-Walter, DEGENHARDT, Louisa, DEMEKE, Feleke Mekonnen, DEMIS, Asmamaw Bizuneh, DEMISSIE, Dereje Bayissa, DEMOZ, Gebre Teklemariam, DERIBE, Kebede, DES JARLAIS, Don, DHUNGANA, Govinda Prasad, DIAZ, Daniel, DJALALINIA, Shirin, DO, Huyen Phuc, DOAN, Linh Phuong, DUBER, Herbert, DUBEY, Manisha, DUBLJANIN, Eleonora, DUKEN, Eyasu Ejeta, DUKO ADEMA, Bereket, EFFIONG, Andem, EFTEKHARI, Aziz, EL SAYED ZAKI, Maysaa, EL-JAAFARY, Shaimaa I, EL-KHATIB, Ziad, ELSHARKAWY, Aisha, ENDRIES, Aman Yesuf, ESKANDARIEH, Sharareh, EYAWO, Oghenowede, FARZADFAR, Farshad, FATIMA, Batool, FENTAHUN, Netsanet, FERNANDES, Eduarda, FILIP, Irina, FISCHER, Florian, FOLAYAN, Morenike Oluwatoyin, FOROUTAN, Masoud, FUKUMOTO, Takeshi, FULLMAN, Nancy, GARCIA-BASTEIRO, Alberto L, GAYESA, Reta Tsegaye, GEBREMEDHIN, Ketema Bizuwork, GEBREMESKEL, Gebreamlak Gebremedhn Gebremedhn, GEBREYOHANNES, Kelali Kalaye, GEDEFAW, Getnet Azeze, GELAW, Belayneh K, GESESEW, Hailay Abrha, GETA, Birhanu, GEZAE, Kebede Embaye, GHADIRI, Keyghobad, GHASHGHAEE, Ahmad, GININDZA, Themba TG, GUGNANI, Harish Chander, GUIMARÃES, Rafael Alves, HAILE, Michael Tamene, HAILU, Gessessew Bugssa, HAJ-MIRZAIAN, Arvin, HAJ-MIRZAIAN, Arya, HAMIDI, Samer, HANDANAGIC, Senad, HANDISO, Demelash Woldeyohannes, HANFORE, Lolemo Kelbiso, HASANZADEH, Amir, HASSANKHANI, Hadi, HASSEN, Hamid Yimam, HAY, Simon I, HENOK, Andualem, HOANG, Chi Linh, HOSGOOD, H Dean, HOSSEINZADEH, Mehdi, HSAIRI, Mohamed, IBITOYE, Segun Emmanuel, IDRISOV, Bulat, IKUTA, Kevin S, ILESANMI, Olayinka Stephen, IRVANI, Seyed Sina Naghibi, IWU, Chinwe Juliana, JACOBSEN, Kathryn H, JAMES, Spencer L, JENABI, Ensiyeh, JHA, Ravi Prakash, JONAS, Jost B, JORJORAN SHUSHTARI, Zahra, KABIR, Ali, KABIR, Zubair, KADEL, Rajendra, KASAEIAN, Amir, KASSA, Belete, KASSA, Getachew Mullu, KASSA, Tesfaye Dessale, KAYODE, Gbenga A, KEBEDE, Mihiretu M, KEFALE, Adane Teshome, KENGNE, Andre Pascal, KHADER, Yousef Saleh, KHAFAIE, Morteza Abdullatif, KHALID, Nauman, KHAN, Ejaz Ahmad, KHAN, Gulfaraz, KHAN, Junaid, KHANG, Young-Ho, KHATAB, Khaled, KHAZAEI, Salman, KHOJA, Abdullah T, KIADALIRI, Aliasghar A, KIM, Yun Jin, KISA, Adnan, KISA, Sezer, KOCHHAR, Sonali, KOMAKI, Hamidreza, KOUL, Parvaiz A, KOYANAGI, Ai, KUATE DEFO, Barthelemy, KUMAR, G Anil, KUMAR, Manasi, KUUPIEL, Desmond, LAL, Dharmesh Kumar, LEE, Jane Jean-Hee, LENJEBO, Tsegaye Lolaso, LESHARGIE, Cheru Tesema, MACARAYAN, Erlyn Rachelle King, MADDISON, Emilie R, MAGDY ABD EL RAZEK, Hassan, MAGIS-RODRIGUEZ, Carlos, MAHASHA, Phetole Walter, MAJDAN, Marek, MAJEED, Azeem, MALEKZADEH, Reza, MANAFI, Navid, MAPOMA, Chabila Christopher, MARTINS-MELO, Francisco Rogerlândio, MASAKA, Anthony, MAYENGA, Emmanuel Ngassa Laurent, MEHTA, Varshil, MELES, Gebrekiros Gebremichael, MELES, Hagazi Gebre, MELESE, Addisu, MELKU, Mulugeta, MEMIAH, Peter TN, MEMISH, Ziad A, MENA, Alemayehu Toma, MENDOZA, Walter, MENGISTU, Desalegn Tadese, MENGISTU, Getnet, MERETOJA, Tuomo J, MESTROVIC, Tomislav, MILLER, Ted R, MOAZEN, Babak, MOHAJER, Bahram, MOHAMADI-BOLBANABAD, Amjad, MOHAMMAD, Karzan Abdulmuhsin, MOHAMMAD, Yousef, MOHAMMAD DARWESH, Aso, MOHAMMAD GHOLI MEZERJI, Naser, MOHAMMADI, Moslem, MOHAMMADIBAKHSH, Roghayeh, MOHAMMADOO-KHORASANI, Milad, MOHAMMED, Jemal Abdu, MOHAMMED, Shafiu, MOHEBI, Farnam, MOKDAD, Ali H, MOODLEY, Yoshan, MOOSSAVI, Maryam, MORADI, Ghobad, MORADI-LAKEH, Maziar, MOSCHOS, Marilita M, MOSSIE, Tilahun Belete, MOUSAVI, Seyyed Meysam, MUCHIE, Kindie Fentahun, MULUNEH, Atalay Goshu, MURIITHI, Moses K, MUSTAFA, Ghulam, MUTHUPANDIAN, Saravanan, NAGARAJAN, Ahamarshan Jayaraman, NAIK, Gurudatta, NAJAFI, Farid, NAZARI, Javad, NDWANDWE, Duduzile Edith, NGUYEN, Cuong Tat, NGUYEN, Huong Lan Thi, NGUYEN, Son Hoang, NGUYEN, Trang Huyen, NINGRUM, Dina Nur Anggraini, NIXON, Molly R, NNAJI, Chukwudi A, NOROOZI, Mehdi, NOUBIAP, Jean Jacques, NOUROLLAHPOUR SHIADEH, Malihe, OBSA, Mohammed Suleiman, ODAME, Emmanuel Ankrah, OFORI-ASENSO, Richard, OGBO, Felix Akpojene, OKORO, Anselm, OLADIMEJI, Olanrewaju, OLAGUNJU, Andrew T, OLAGUNJU, Tinuke O, OLUM, Solomon, OPPONG ASANTE, Kwaku Oppong Asante, OREN, Eyal, OTSTAVNOV, Stanislav S, PA, Mahesh, PADUBIDRI, Jagadish Rao, PAKHALE, Smita, PAKPOUR, Amir H, PATEL, Sangram Kishor, PAULOS, Kebreab, PEPITO, Veincent Christian Filipino, PEPRAH, Emmanuel K, PIROOZI, Bakhtiar, POURSHAMS, Akram, QORBANI, Mostafa, RABIEE, Mohammad, RABIEE, Navid, RADFAR, Amir, RAFAY, Anwar, RAFIEI, Alireza, RAHIM, Fakher, RAHIMI-MOVAGHAR, Afarin, RAHIMI-MOVAGHAR, Vafa, RAHMAN, Sajjad ur, RANABHAT, Chhabi Lal, RAWAF, Salman, REIS, Cesar, RENJITH, Vishnu, RETA, Melese Abate, REZAI, Mohammad Sadegh, RIOS GONZÁLEZ, Carlos Miguel, RORO, Elias Merdassa, ROSTAMI, Ali, RUBINO, Salvatore, SAEEDI MOGHADDAM, Sahar, SAFARI, Saeed, SAGAR, Rajesh, SAHRAIAN, Mohammad Ali, SALEM, Marwa R Rashad, SALIMI, Yahya, SALOMON, Joshua A, SAMBALA, Evanson Zondani, SAMY, Abdallah M, SARTORIUS, Benn, SATPATHY, Maheswar, SAWHNEY, Monika, SAYYAH, Mehdi, SCHUTTE, Aletta Elisabeth, SEPANLOU, Sadaf G, SEYEDMOUSAVI, Seyedmojtaba, SHABANINEJAD, Hosein, SHAHEEN, Amira A, SHAIKH, Masood Ali, SHALLO, Seifadin Ahmed, SHAMSIZADEH, Morteza, SHARIFI, Hamid, SHIBUYA, Kenji, SHIN, Jae Il, SHIRKOOHI, Reza, SILVA, Diego Augusto Santos, SILVEIRA, Dayane Gabriele Alves, SINGH, Jasvinder A, SISAY, Malede Mequanent M, SISAY, Mekonnen, SISAY, Solomon, SMITH, Amanda E, SOKHAN, Anton, SOMAYAJI, Ranjani, SOSHNIKOV, Sergey, STEIN, Dan J, SUFIYAN, Mu'awiyyah Babale, SUNGUYA, Bruno F, SYKES, Bryan L, TADESSE, Birkneh Tilahun, TADESSE, Degena Bahrey, TAMIRAT, Koku Sisay, TAVEIRA, Nuno, TEKELEMEDHIN, Shishay Wahdey, TEMESGEN, Habtamu Denekew, TESFAY, Fisaha Haile, TESHALE, Manaye Yihune, THAPA, Subash, TLAYE, Kenean Getaneh, TOPP, Stephanie M, TOVANI-PALONE, Marcos Roberto, TRAN, Bach Xuan, TRAN, Khanh Bao, ULLAH, Irfan, UNNIKRISHNAN, Bhaskaran, UTHMAN, Olalekan A, VEISANI, Yousef, VLADIMIROV, Sergey Konstantinovitch, WADA, Fiseha Wadilo, WAHEED, Yasir, WELDEGWERGS, Kidu Gidey, WELDESAMUEL, Girmay Teklay T, WESTERMAN, Ronny, WIJERATNE, Tissa, WOLDE, Haileab Fekadu, WONDAFRASH, Dawit Zewdu, WONDE, Tewodros Eshete, WONDMAGEGN, Berhanu Yazew, YESHANEW, Addisu Gize, YILMA, Mekdes Tigistu, YIMER, Ebrahim M, YONEMOTO, Naohiro, YOTEBIENG, Marcel, YOUM, Yoosik, YU, Chuanhua, ZAIDI, Zoubida, ZARGHI, Afshin, ZENEBE, Zerihun Menlkalew, ZEWALE, Taye Abuhay, ZIAPOUR, Arash, ZODPEY, Sanjay, NAGHAVI, Mohsen, VOLLSET, Stein Emil, WANG, Haidong, LIM, Stephen S, KYU, Hmwe Hmwe and MURRAY, Christopher JL (2019). Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. The Lancet HIV. [Article]

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Abstract
Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980–2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package—a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce age-sex-specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1·95 million deaths (95% uncertainty interval 1·87–2·04) and has since decreased to 0·95 million deaths (0·91–1·01) in 2017. New cases of HIV globally peaked in 1999 (3·16 million, 2·79–3·67) and since then have gradually decreased to 1·94 million (1·63–2·29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36·8 million (34·8–39·2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65·7% in Lesotho to 85·7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact. Funding Bill & Melinda Gates Foundation, National Institute of Mental Health of the US National Institutes of Health (NIH), and the National Institute on Aging of the NIH.
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